Christopher Radcliffe, MD
Clinical FellowAbout
Research
Publications
2025
Lactobacillus Bacteremia and Endovascular Infections: A Retrospective Study of 100 Patients.
Radcliffe CV, Anahtar MN, Hohmann EL, Turbett SE, Dugdale CM, Paras ML. Lactobacillus Bacteremia and Endovascular Infections: A Retrospective Study of 100 Patients. Open Forum Infect Dis 2025, 12: ofaf466. PMID: 40852136, DOI: 10.1093/ofid/ofaf466.Peer-Reviewed Original Research
2024
Experience with expanded use of oritavancin in a tertiary hospital: indications, tolerability and outcomes
Bandaranayake T, Radcliffe C, Cvercko M, Golden M, Hao R. Experience with expanded use of oritavancin in a tertiary hospital: indications, tolerability and outcomes. JAC-Antimicrobial Resistance 2024, 6: dlae174. PMID: 39493938, PMCID: PMC11524893, DOI: 10.1093/jacamr/dlae174.Peer-Reviewed Original ResearchDose of oritavancinInfective endocarditisTreatment of acute bacterial skinBacterial infectionsLipoglycopeptide antibacterial agentTertiary care medical centreAcute bacterial skinGram-positive bacterial infectionsInvasive bacterial infectionsTreatment failure rateNinety-five adult patientsSoft tissue infectionsProsthetic joint infectionGram-positive organismsBacterial skinDrug discontinuationTissue infectionsRetrospective studyAdult patientsClinical outcomesAdverse eventsOritavancinOff-labelJoint infectionTreat infectionsTravel Medicine for Immunocompromised Travelers: An Essential Layer of Protection
Radcliffe C, Kotton CN. Travel medicine for immunocompromised travelers: An essential layer of protection. Curr Treat Options Infect Dis. 2025;17(2). doi: 10.1007/s40506-024-00277-yPeer-Reviewed Original ResearchEn Garde or On Board? Travel Medicine for Immunocompromised Patients in the COVID-19 Era.
Radcliffe C, Kotton CN. En Garde or On Board? Travel Medicine for Immunocompromised Patients in the COVID-19 Era. Ann Intern Med 2024, 177: 667-669. PMID: 38588541, DOI: 10.7326/M24-0256.Peer-Reviewed Original Research
2023
Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging
Kumar A, Wang J, Esterly A, Radcliffe C, Zhou H, Wyk B, Allore H, Tsang S, Barakat L, Mohanty S, Zhao H, Shaw A, Zapata H. Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging. Aging 2023, 15: 7866-7908. PMID: 37606991, PMCID: PMC10497004, DOI: 10.18632/aging.204927.Peer-Reviewed Original ResearchConceptsDectin-1 stimulationDendritic cellsHIV-positive older adultsOlder adultsDectin-1 functionDistinct immune signaturesDistinct inflammatory signatureMonocytes of HIVCohort of HIVIFN-α productionPro-inflammatory environmentIFN-γ responsesPro-inflammatory phenotypeInnate immune receptorsDistinct gene signaturesStimulation of monocytesInflammatory signatureImmune signaturesHIV infectionIL-12Macrophage signatureCytokine productionIL-6Cytokine increaseHIV
2022
Antiviral Treatment of Coronavirus Disease-2019 Pneumonia
Radcliffe C, Malinis M, Azar M. Antiviral Treatment of Coronavirus Disease-2019 Pneumonia. Clinics In Chest Medicine 2022, 44: 279-297. PMID: 37085220, PMCID: PMC9701636, DOI: 10.1016/j.ccm.2022.11.008.Peer-Reviewed Original ResearchConceptsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCoronavirus diseaseCoronavirus 2 infectionDirect acting antiviralsAdditional clinical trialsReal-world studyCOVID-19Acting antiviralsAntiviral treatmentTherapeutic optionsAvailable therapiesClinical trialsDisease progressionInpatient treatmentHigh riskEarly pandemicMonoclonal antibodiesDiseaseTreatmentMorbidityPandemicPneumoniaOutpatientsReal-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection.
Medvedeva N, Radcliffe C, Malinis M, Chen M, Azar M. Real-world assessment of the clinical utility of whole body 18F-FDG PET/CT in the diagnosis of infection. PLOS ONE 2022, 17: e0277403. PMID: 36374789, PMCID: PMC9662742, DOI: 10.1371/journal.pone.0277403.Peer-Reviewed Original ResearchConceptsPET/CTClinical impactFDG PET/CTRetrospective chart reviewEmission tomography/Evaluation of infectionDiagnosis of infectionVariety of syndromesInfectious indicationsChart reviewCommon indicationTomography useUnknown etiologyEndovascular infectionTomography/Antimicrobial managementClinical indicationsReal-world assessmentInclusion criteriaClinical utilityPatientsTreatment managementUnknown originInfectionCTReal-world experience with available, outpatient COVID-19 therapies in solid organ transplant recipients during the omicron surge
Radcliffe C, Palacios CF, Azar MM, Cohen E, Malinis M. Real-world experience with available, outpatient COVID-19 therapies in solid organ transplant recipients during the omicron surge. American Journal Of Transplantation 2022, 22: 2458-2463. PMID: 35583664, PMCID: PMC9348251, DOI: 10.1111/ajt.17098.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOral antiviral agentsOrgan transplant recipientsOutpatient therapyTransplant recipientsAntiviral agentsCOVID-19-related morbidityMonoclonal antibodiesKidney transplant recipientsRate of hospitalizationCOVID-19 therapyReal-world effectivenessSARS-CoV-2 pandemicCOVID-19 diagnosisModerate diseaseRetrospective reviewMean ageOutpatient settingClinical trialsSubstantial burdenTherapyCoronavirus diseaseMean timeHealthcare systemReal-world experienceDematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis
Radcliffe C, Radcliffe AJ, Azar MM, Grant M. Dematiaceous fungal infections in solid organ transplantation: Systematic review and Bayesian meta‐analysis. Transplant Infectious Disease 2022, 24: e13819. PMID: 35253959, DOI: 10.1111/tid.13819.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsDematiaceous fungal infectionSoft tissue infectionsFungal infectionsInfectious syndromesSystematic reviewEarly post-transplant periodCentral nervous system infectionCommon infectious syndromesPost-transplant periodNervous system infectionOrgan transplant recipientsSolid organ transplantationEnglish-language reportsInfection typeKidney recipientsLiver recipientsPediatric reportsTransplant recipientsPulmonary infectionSystem infectionTissue infectionsWorse prognosisDisseminated infectionMean ageRectal screening for azole non‐susceptible Candida species in patients undergoing liver transplantation
Radcliffe C, Patel KK, Azar MM, Koff A, Belfield KD, Peaper DR, Topal JE, Malinis M. Rectal screening for azole non‐susceptible Candida species in patients undergoing liver transplantation. Transplant Infectious Disease 2022, 24: e13811. PMID: 35184347, DOI: 10.1111/tid.13811.Peer-Reviewed Original ResearchConceptsAppropriate antifungal prophylaxisAntifungal prophylaxisRisk factorsTransplant recipientsRectal swabsSolid organ transplant recipientsCommon invasive fungal infectionYale-New Haven HospitalDays of LTTime of LTLiver transplant recipientsOrgan transplant recipientsRetrospective chart reviewMore risk factorsMultiple risk factorsInvasive fungal infectionsNew Haven HospitalPrimary LTLiver transplantationAdult patientsChart reviewLT candidatesRectal screeningCandida infectionsMedian number