Collin Heer, PhD
Associate Research Scientist in Therapeutic RadiologyAbout
Research
Publications
2025
Mitoregulin Promotes Cell Cycle Progression in Non-Small Cell Lung Cancer Cells.
Stein CS, Linzer CR, Heer CD, Witmer NH, Cochran JD, Spitz DR, Boudreau RL. Mitoregulin Promotes Cell Cycle Progression in Non-Small Cell Lung Cancer Cells. Int J Mol Sci 2025, 26 PMID: 40076565, DOI: 10.3390/ijms26051939.Peer-Reviewed Original Research
2021
Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD().
Roboon J, Hattori T, Ishii H, Takarada-Iemata M, Nguyen DT, Heer CD, O'Meally D, Brenner C, Yamamoto Y, Okamoto H, Higashida H, Hori O. Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD(). J Neurochem 2021, 158: 311-327. PMID: 33871064, DOI: 10.1111/jnc.15367.Peer-Reviewed Original ResearchAvasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide.
Sishc BJ, Ding L, Nam TK, Heer CD, Rodman SN, Schoenfeld JD, Fath MA, Saha D, Pulliam CF, Langen B, Beardsley RA, Riley DP, Keene JL, Spitz DR, Story MD. Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide. Sci Transl Med 2021, 13 PMID: 33980575, DOI: 10.1126/scitranslmed.abb3768.Peer-Reviewed Original Research
2020
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity.
Heer CD, Sanderson DJ, Voth LS, Alhammad YMO, Schmidt MS, Trammell SAJ, Perlman S, Cohen MS, Fehr AR, Brenner C. Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. The Journal Of Biological Chemistry 2020, 295: 17986-17996. PMID: 33051211, PMCID: PMC7834058, DOI: 10.1074/jbc.RA120.015138.Peer-Reviewed Original ResearchLetting off electrons to cope with metabolic stress.
Heer CD, Brenner C. Letting off electrons to cope with metabolic stress. Nat Metab 2020, 2: 485-486. PMID: 32694728, DOI: 10.1038/s42255-020-0207-8.Commentaries, Editorials and LettersSuccinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate.
Cramer-Morales KL, Heer CD, Mapuskar KA, Domann FE. Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate. J Exp Pathol (Wilmington) 2020, 1: 60-70. PMID: 33585836.Peer-Reviewed Original Research
2018
Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy.
Zhu Y, Dean AE, Horikoshi N, Heer C, Spitz DR, Gius D. Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy. J Clin Invest 2018, 128: 3682-3691. PMID: 30168803, DOI: 10.1172/JCI120844.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSuperoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.
Heer CD, Davis AB, Riffe DB, Wagner BA, Falls KC, Allen BG, Buettner GR, Beardsley RA, Riley DP, Spitz DR. Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner. Antioxidants (Basel) 2018, 7 PMID: 29351198, DOI: 10.3390/antiox7010018.Peer-Reviewed Original Research
2015
SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD.
Cramer-Morales K, Heer CD, Mapuskar KA, Domann FE. SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD. Free Radic Biol Med 2015, 89: 379-86. PMID: 26208779, DOI: 10.1016/j.freeradbiomed.2015.07.017.Peer-Reviewed Original Research
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