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David P. Smith Professor Emeritus of Dermatology
Biography
UPDATE: A graduate of Yale College and the McGill University Faculty of Medicine in Montreal, Leffell completed his residency training in internal medicine at Cornell Cooperating Hospitals and then in dermatology at Yale-New Haven Hospital. He completed an NIH post-doctoral research fellowship in dermatology at Yale followed by a clinical fellowship in dermatologic surgery at the University of Michigan Medical School in Ann Arbor. Author of the popular book "Total Skin," Leffell is an expert clinician, specializing in skin cancer and melanoma diagnosis and surgical treatment using the Mohs micrographic technique. The Cutaneous Oncology Unit that he founded in 1988 now performs specialized surgical treatment on more than 3,500 patients annually. His major clinical interest is the management of skin cancer, including basal cell cancer, squamous cell cancer and melanoma. In 1996 Leffell was a member of the research group that discovered the skin cancer gene known as PTCH. In addition, he has conducted collaborative research clarifying the role of ultraviolet radiation in skin cancer and skin aging. Author of more than 200 publications, Leffell has also done research on epidemiologic aspects of skin cancer and wound healing. Dr. Leffell was the first CEO of the Yale Medical Group (now Yale Medicine) and served as Deputy Dean for Clinical Affairs at Yale for almost a decade.
Appointments
Dermatology 2
EmeritusPrimaryDermatology 2
Senior Research ScientistSecondary
Other Departments & Organizations
- All Institutions
- Cutaneous Oncology Program
- Dermatologic Laser Surgery Program
- Dermatologic Surgery
- Dermatology 2
- Genomics, Genetics, and Epigenetics
- Head and Neck Cancers Program
- Mohs Surgery
- Skin & Kidney Cancer Program
- Yale Cancer Center
- Yale Medicine
- Yale New Haven Health System
Education & Training
- AuD
- aud, ssssss (2025)
- Fellow
- University of Michigan Medical School, Ann Arbor, MI (1988)
- N.I.H Postdoctoral Fellow
- Yale University School of Medicine, New Haven, CT (1987)
- Fellowship
- Yale New Haven Hospital, New Haven, CT (1987)
- Resident
- Yale-New Haven Hospital, New Haven, CT (1986)
- Residency
- Yale New Haven Hospital, New Haven, CT (1986)
- Resident
- Cornell Cooperating Hospitals (1984)
- Residency
- Cornell Cooperating Hospitals (1984)
- Intern
- Cornell Cooperating Hospitals (1982)
- MD
- McGill University Faculty of Medicine (1981)
- BS
- Yale College, Biology (1977)
Research
Overview
When I founded the Dermatologic Surgery program at Yale in 1988, my goal was to combine state of the art patient care with clinical research. We often talk about bench to bedside as the framework for discovery in medicine but in fact most innovations related to disease proceed the other way: from bedside to bench. A doctor recognizes a pattern in a particular disease or makes a novel observation in a patient and that raises questions for investigation in the laboratory. Early in my career I observed an increase in basal cell cancer in young women. This was unusual for a disease typically noted in older men. Investigation into sun practices and related issues became the basis for a component of a SPORE grant that the department was awarded. Because we treat a very large number of skin cancers and melanoma and perform reconstructive surgery, a large focus of our research has also been on wound healing. We have published on the use of artificial skin substitutes to facilitate healing and I am involved with a commercial entity with a connexin43 molecule currently in clinical trials. In a broad sense my research collaborations extend from skin cancer in the immune compromised, to the biology of skin cancer in general and its epidemiology to the development of innovative treatments.
Medical Research Interests
Academic Achievements & Community Involvement
statement
Clinical Care
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Teaching & Mentoring
- Teaching
- 1 Course for Graduate Students
- 12 Average Instructional Hours per Year
- Mentoring
- 1 Mentored Student and Faculty
Teaching
Clinical Biopsychosocial Approach to Health (BAH) Integrated Clerkship Block
Course DirectorInpatient Clinical Setting4/1/2025 - PresentForGraduate12 Average Instructional Hours Per YearBiopsychosocial Approach to the Patient (BAH) is a 12-week integrated clerkship block comprised of Psychology and Primary Care. Integration of training in Primary Care and Psychiatry occurs in two areas. First, in didactics, all students assemble together to complete “Top Ten” workshops on topics spanning both disciplines, e.g., assessment of competency, treatment of chronic pain, motivational interviewing, diagnosis and treatment of somatic symptoms, addressing social determinants of health. Additionally, students participate in three individual workshops a) introduction and rationale for the biopsychosocial approach with readings (e.g., George Engel, Barbara Starfield), b) clinical approach to the biopsychosocial model and c) how patients access community health and psychiatric resources. In the clinical realm, many sites have embedded psychiatric services, e.g., West Haven VA Medical Center, the New Haven Health Consortium, Cornell Scott Hill Federally Qualified Health Center, and Yale Internal Medicine Associates. Course Directors (CDs) communicate with preceptors at all sites before students arrive, emphasizing the clerkship’s goal to teach a holistic approach to patient care. Additionally, to promote exchange of ideas across Primary Care and Psychiatry faculty, CDs prepare and host regular evening faculty development events focusing on topics of interest to both Primary Care and Psychiatry faculty.
Mentoring
Anhelina Bohush
Associate Research Scientist2026 - Present
News & Links
Advancing Our Academic Health System - An Enterprise Town Hall 11-16-2023
Watch the Nov. 16 Alignment Town Hall
Nancy Brown, Dean of Yale School of Medicine (YSM), and Christopher O’Connor, CEO and President of Yale New Haven Health System (YNHHS), provide an overview of the YSM and YNHHS alignment efforts and answer questions from the town hall participants.
Media
Advancing Our Academic Health System - An Enterprise Town Hall 11-16-2023
Watch the Nov. 16 Alignment Town Hall
Nancy Brown, Dean of Yale School of Medicine (YSM), and Christopher O’Connor, CEO and President of Yale New Haven Health System (YNHHS), provide an overview of the YSM and YNHHS alignment efforts and answer questions from the town hall participants.
News
- December 01, 2025
Long Form feeds check
- December 01, 2025
New ticket to see analytics
- October 16, 2025
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- October 13, 2025
Check Reach results
Get In Touch
Contacts
Cutaneous Oncology Program
New mailing address
efg, dsfg 245
United States
Dermatology 2
40 Temple Street,
New Haven, CT 06510
United States
Administrative Support
Supported Faculty
Locations
Yale Dermatologic Surgery
Academic Office
Temple Medical Center
40 Temple Street, Ste 5A
New Haven, CT 06510
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.