2015
Dopamine/Adenosine Interactions Related to Tremor in Animal Models of Parkinsonism
Salamone J, Podurgiel S, Long L, Nunes E, Correa M. Dopamine/Adenosine Interactions Related to Tremor in Animal Models of Parkinsonism. Current Topics In Neurotoxicity 2015, 10: 149-162. DOI: 10.1007/978-3-319-20273-0_8.Peer-Reviewed Original ResearchAdenosine A2A receptor antagonistTremulous jaw movementsA2A receptor antagonistsAdenosine A2A receptorsAnimal modelsReceptor antagonistA2A receptorsAdenosine A2A receptor knockout miceA2A receptor knockout miceTremulous jaw movement modelAnti-tremor effectJaw movementsReceptor knockout miceHuman clinical studiesAdenosine A2A antagonistsAntiparkinsonian effectsCholinomimetic stimulationOral tremorIntrastriatal injectionDopamine depletionCGS 21680Antiparkinsonian agentsDopamine antagonistsClinical studiesA2A antagonists
2012
The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation
Salamone J, Correa M, Randall P, Nunes E, Pardo M, Lopez-Cruz L. The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation. 2012, 493-512. DOI: 10.1007/978-1-4614-3903-5_23.Peer-Reviewed Original ResearchIntra-accumbens injectionsDA depletionReceptor antagonistAccumbens DA depletionsEffort-related processesAdenosine A2A receptor antagonistA1 receptor antagonistAdenosine A2A agonistDA D2 antagonistsA2A receptor antagonistsRole of adenosineAdenosine A2A receptorsEffort-related decision makingEffort-related choice behaviorBrain dopamineNeuromodulator adenosineD2 antagonistD2 antagonismA2A agonistNucleus accumbensStriatal circuitsTendency of ratsMotivational symptomsA2A receptorsPathological aspects
2010
Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
Nunes E, Randall P, Santerre J, Given A, Sager T, Correa M, Salamone J. Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism. Neuroscience 2010, 170: 268-280. PMID: 20600675, PMCID: PMC3268040, DOI: 10.1016/j.neuroscience.2010.05.068.Peer-Reviewed Original ResearchConceptsEffects of dopamineEffects of ecopipamSame striatal neuronsEffects of adenosineAbility of adenosineEffort-related impairmentsEffort-related choiceFood-seeking behaviorEffort-related choice behaviorConcurrent leverChow intakeDA transmissionSelective adenosine antagonistsStriatal neuronsReceptor antagonistRodent chowDopamine D1D2 antagonismPsychiatric symptomsPsychomotor slowingAdenosine antagonistEffort-related processesBrain circuitryAntagonistMesolimbic dopamine
2009
Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism
Salamone J, Farrar A, Font L, Patel V, Schlar D, Nunes E, Collins L, Sager T. Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism. Behavioural Brain Research 2009, 201: 216-222. PMID: 19428636, PMCID: PMC2806666, DOI: 10.1016/j.bbr.2009.02.021.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine A1 Receptor AntagonistsAdenosine A2 Receptor AntagonistsAnalysis of VarianceAnimalsBehavior, AnimalCaffeineCentral Nervous System AgentsChoice BehaviorConditioning, OperantDopamine AntagonistsDopamine D2 Receptor AntagonistsFeeding BehaviorHaloperidolMaleMotivationPurinesRatsRats, Sprague-DawleyReinforcement ScheduleXanthinesConceptsAdenosine antagonist caffeineEffort-related effectsAntagonist DPCPXAntagonist caffeineDopamine D2 antagonismPreferred lab chowEffects of dopamineEffects of haloperidolAbsence of haloperidolRatio 5 scheduleEffort-related choice behaviorStriatal neuronsReceptor antagonistStriatal areasIP injectionD2 antagonismDopamine receptorsLab chowAdenosine A1
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