Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making
Oemisch M, Seo H. Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making. ELife 2024, 12: rp87529. PMID: 38700991, PMCID: PMC11068354, DOI: 10.7554/elife.87529.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntranasalAnimalsAntidepressive AgentsBehavior, AnimalDecision MakingInjections, IntramuscularKetamineMacaca mulattaMaleConceptsDose of ketamineAntidepressant effectsKetamine's antidepressant actionPotential antidepressant effectsRapid-acting antidepressantsPathophysiology of depressionImpact of negative eventsAntidepressant actionBehavioral perseverationAversive effectsNeuropsychological changesTreating depressionAffect memoryMood statesNegative eventsAdaptive behaviorSynaptic levelAffective eventsTemporal credit assignmentTherapeutic dosesDepressionCognitive aspectsInhibitory circuitryBehavioral changesAcute effects
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply