Jason Johnson, MD, MBA, DABR
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Research
Publications
2025
Brain CT for diagnosis of intracranial disease in ambulatory cancer patients: Assessment of the diagnostic value of scanning without contrast prior to with contrast
Wang, E., Darbandi, A., Tu, L., Ballester, L. Y., de Jesus Morales, C., Chen, M., Gule-Monroe, M. K., & Johnson, J. M. Brain CT for diagnosis of intracranial disease in ambulatory cancer patients: Assessment of the diagnostic value of scanning without contrast prior to with contrast. American Journal of Neuroradiology. Accepted 16 August 2025; (in press).Peer-Reviewed Original Research In PressComparative Accuracy of 18-Gauge versus 20-Gauge Ultrasound-Guided Fine-Needle Aspiration in the Detection of Persistent Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma after Chemoradiation
Nguyen, J., Patel, D., Lano, K., Ansari, S., Wang, E., Yadav, M., Gillison, M., Lai, S., Fuller, C. D., Moreno, A., Gule-Monroe, M. K., & Johnson, J. M. (2025). Comparative accuracy of 18-gauge versus 20-gauge ultrasound-guided fine-needle aspiration in the detection of persistent lymph node metastasis in head and neck squamous cell carcinoma after chemoradiation. American Journal of Neuroradiology. Manuscript accepted for publication.Peer-Reviewed Original Research In PressASNR Consensus Statement: Integrating Neuro-PET Interpretation into Neuroradiology Training and Practice
Ivanidze J, Franceschi AM, Wintermark M, Jordan JE, Aboian M, Anderson J, Assadsangabi R, Benayoun MD, Benzinger TL, Buchpiguel CA, Chiang GC-Y, Ebani EJ, Famuyide A, Galldiks N, Hu LS, Johnson DS, Johnson JM, Khalaf A, Knight-Greenfield A, Kuo P, Lohmann, P, Moradi, F, Nabavizadeh A, Nickerson JP, Perez-Carrillo GJG, Pyatigorskaya N, Raghavan P, Roytman M, Sheperd T, Singh G, Starkey J, Veronesi MC, Whitlow CT, Yildiz S, Zeineh M, Zaharchuk G, Raghavan P, Barajas RF. State of Practice: Integrating Neuro-PET Interpretation into Neuroradiology Training and Practice: A Collaborative, Patient-Centered Approach. AJNR Am J Neuroradiol. Accepted 18 July 2025 (in press).Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsStudy of 18 F-fluciclovine PET for serial assessment of glioblastoma tumor volumes during surgery and radiotherapy.
Dagher SA, Johnson JM, Mohamed RMM, Ansari S, Mawlawi O, Liu HL, Wintermark M, Schellingerhout D, Flynt L, Yeboa DN, Weinberg JS, Ferguson SD, Gule-Monroe MK. Study of 18 F-fluciclovine PET for serial assessment of glioblastoma tumor volumes during surgery and radiotherapy. J Neurooncol 2025 PMID: 40591209, DOI: 10.1007/s11060-025-05146-2.Peer-Reviewed Original ResearchPseudoprogression in Pediatric Spinal Pilocytic Astrocytoma and Myxopapillary Ependymoma after Proton Therapy: A Case Series.
Lee KL, Johnson JM, Kralik SF, Ramírez Mateo SV, Grosshans DR, McAleer MF, Zaky W, Baxter PA, Lin FY, Chintagumpala M, Paulino AC, McGovern SL. Pseudoprogression in Pediatric Spinal Pilocytic Astrocytoma and Myxopapillary Ependymoma after Proton Therapy: A Case Series. Pediatr Blood Cancer 2025, e31873. PMID: 40563211, DOI: 10.1002/pbc.31873.Peer-Reviewed Original ResearchTherapy, Safety, and Logistics of Preoperative vs Postoperative Stereotactic Radiation Therapy: A Preliminary Analysis of a Randomized Clinical Trial.
Yeboa DN, Li J, Lin R, Prabhu SS, Beckham TH, Woodhouse K, Swanson TA, Weinberg JS, Wang X, Chi X, Ejezie CL, Suki D, Wang C, Ene C, McCutcheon IE, McGovern S, McAleer MF, Tom M, Ghia A, Perni S, Jiang W, De B, Chung C, Kim BYS, O'Brien BJ, Huse JT, Wefel JS, Court L, Tawbi H, Janku F, Guha-Thakurta N, Debnam JM, Johnson J, Taslicay CA, Alvarez-Breckenridge C, Raza SM, Heimberger AB, DeMonte F, North R, Briere TM, de Groot JF, Sawaya R, Grosshans D, Lang FF, Rao G, Ferguson SD. Therapy, Safety, and Logistics of Preoperative vs Postoperative Stereotactic Radiation Therapy: A Preliminary Analysis of a Randomized Clinical Trial. JAMA Oncol 2025 PMID: 40531511, DOI: 10.1001/jamaoncol.2025.1770.Peer-Reviewed Original ResearchMolecular alterations in IDH-mutant astrocytoma: A multi-institutional retrospective study.
Lam K, Ozkizilkaya HI, Milton DR, Dono A, Liu Y, Kundu S, Kumar VA, Johnson JM, Esquenazi Y, Patel CB, Ballester LY. Molecular alterations in IDH-mutant astrocytoma: A multi-institutional retrospective study. Neurooncol Adv 2025, 7: vdaf088. PMID: 40575414, DOI: 10.1093/noajnl/vdaf088.Peer-Reviewed Original ResearchDepletion of effector regulatory T cells associates with major response to induction dual immune checkpoint blockade.
Jiang X, Rudqvist N, Jiang B, Ye S, He S, Liang Q, Dou J, Williams M, Dunn J, Johnson J, Akagi K, Xiao W, Liang S, Elayavalli S, Sun B, Parra E, Ferrarotto R, Garden A, Fuller C, Reddy J, Gross N, Lango M, Leung C, Liu S, Liu D, Li M, Lee J, Curran M, Phan J, Chen K, Gillison M. Depletion of effector regulatory T cells associates with major response to induction dual immune checkpoint blockade. Cancer Discovery 2025, of1-of24. PMID: 40249124, DOI: 10.1158/2159-8290.cd-24-1390.Peer-Reviewed Original ResearchTissue-resident memoryCD8+ T cell clonotypesIntratumoral CD8+ T cellsComplete metabolic response rateDual immune checkpoint blockadeCD8+ T cellsResponse rateAnti-PD-1Concurrent with radiotherapyHistopathological response rateMetabolic response rateOropharyngeal carcinoma patientsAnti-CTLA-4Immune checkpoint blockadeProgression-free survivalPhase 2 trialT cell clonotypesCo-primary endpointsCheckpoint blockadeEffector memoryInduction immunotherapyTumor-reactiveRegulatory TTumor viabilityCarcinoma patientsInternational multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation
Sahin O, Kamel S, Wahid K, Dede C, Taku N, He R, Naser M, Sharafi C, Mäkitie A, Kann B, Kaski K, Sahlsten J, Jaskari J, Amit M, Chronowski G, Diaz E, Garden A, Goepfert R, Guenette J, Gunn G, Hirvonen J, Hoebers F, Hutcheson K, Guha‐Thakurta N, Johnson J, Kaya D, Khanpara S, Nyman K, Lai S, Lango M, Learned K, Lee A, Lewis C, Maniakas A, Moreno A, Myers J, Phan J, Pytynia K, Rosenthal D, Sandulache V, Schellingerhout D, Shah S, Sikora A, Mohamed A, Chen M, Fuller C, Group M. International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation. Cancer 2025, 131: e35815. PMID: 40159431, PMCID: PMC12067423, DOI: 10.1002/cncr.35815.Peer-Reviewed Original ResearchConceptsPathologic extranodal extensionOropharyngeal cancerExtranodal extensionComputed tomographyClinician specialtyHPV-positive OPC patientsHuman papillomavirus (HPV)-positive oropharyngeal cancerHPV-positive oropharyngeal cancerReceiver operating characteristic curveArea under the receiver operating characteristic curveInter-observer variabilityOPC patientsNodal necrosisPrognostic factorsRadiological criteriaInterobserver agreementDiagnostic performanceBrier scoreCT imagesFleiss' kappaCharacteristic curvePredictive signLogistic regressionPatientsCancerA Prospective Study of Conventionally Fractionated Dose Constraints for Reirradiation of Primary Brain Tumors in Children
McGovern S, Johnson J, Luo D, Nguyen K, McAleer M, Paulino A, Grosshans D, Baxter P, Zaky W, Thall P, Mahajan A. A Prospective Study of Conventionally Fractionated Dose Constraints for Reirradiation of Primary Brain Tumors in Children. International Journal Of Radiation Oncology • Biology • Physics 2025, 121: e13-e14. DOI: 10.1016/j.ijrobp.2024.11.049.Peer-Reviewed Original ResearchDose-volume constraintsSymptomatic brain necrosisRecurrent brain tumorsBrain tumorsBrain necrosisPrimary endpointDose constraintsProton therapyProspective studyRecurrent pediatric brain tumorsMedian overall survivalMedian prescription doseCourse of radiationResults Median ageTreated with radiationPediatric brain tumorsPrimary brain tumorProgression of diseaseBrain reirradiationDosimetric guidelinesDose escalationPrescription doseOverall survivalMedian intervalProspective trials
Academic Achievements & Community Involvement
Clinical Care
Overview
Jason Johnson, MD, is a neuroradiologist who specializes in imaging techniques to diagnose and evaluate conditions affecting the brain and nervous system, including brain tumors, stroke, and other neurological disorders.
He utilizes advanced imaging methods to provide detailed insights into these conditions, aiding in accurate diagnosis and effective treatment planning.
An associate professor of radiology and biomedical imaging at Yale School of Medicine, Dr. Johnson completed his medical training at the University of Arizona, followed by a residency in radiology at the University of Vermont and fellowship training in neuroradiology at both the University of California, San Francisco, and Massachusetts General Hospital/Harvard Medical School.
Dr. Johnson has been recognized with the Magna Cum Laude Merit Award by the International Society of Magnetic Resonance in Medicine.
Clinical Specialties
Neuroradiology
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