Featured Publications
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circulation Research 2022, 130: 1204-1229. PMID: 35420918, PMCID: PMC10032582, DOI: 10.1161/circresaha.121.319949.Peer-Reviewed Original ResearchConceptsMechanism of injuryIntracerebral hemorrhageUltra-early hemostatic therapyInflammatory brain injuryCurrent treatment strategiesIron-induced injuryAnticoagulant useHemostatic therapyHemorrhagic strokeHypertension managementICH therapySurgical managementHigh morbidityPrimary preventionFunctional outcomeICH managementBrain injuryClinical trialsTreatment strategiesPrognostic biomarkerDevastating formDisease pathobiologyInjuryInvasive surgeryOxidative stressImpacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage
Magid-Bernstein J, Beaman CB, Carvalho-Poyraz F, Boehme A, Hod EA, Francis RO, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Roh D. Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage. Blood 2021, 137: 2699-2703. PMID: 33649761, PMCID: PMC9635530, DOI: 10.1182/blood.2020008381.Peer-Reviewed Original ResearchConceptsABO-incompatible platelet transfusionsIntracerebral hemorrhagePlatelet transfusionsPlatelet recoveryABO-compatible transfusionsSingle-center cohortOdds of mortalityABO-incompatible transfusionLow platelet recoveryNeurological outcomeOngoing bleedingABO compatibilityICH outcomeMedication effectsTransfusionPoor mRSPatientsHemorrhageOutcomesUnderlying mechanismFurther investigationBleedingCohortMortalityRecoveryCerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials
Magid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone G, Sheth K, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley D, Kamel H, Ziai WC, Murthy SB. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Neurology 2021, 98: e1013-e1020. PMID: 34937780, PMCID: PMC8967392, DOI: 10.1212/wnl.0000000000013247.Peer-Reviewed Original ResearchConceptsSmaller ICH volumeCerebral microbleedsSmall vessel diseaseIntracerebral hemorrhageHematoma expansionHematoma characteristicsICH volumeVessel diseaseNumber of CMBsSmaller baseline hematoma volumesUnderlying small vessel diseasePresence of CMBsCerebral small vessel diseaseAdmission ICH volumeMISTIE III trialPresence of microbleedsClass II evidencePhase 3 trialSeverity of leukoaraiosisPrimary intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataBrain MRI scansLogistic regression modelsAntihypertensive treatment
2023
Guidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage
Parasram M, Park J, Al-Dulaimi M, Magid-Bernstein J. Guidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage. Stroke 2023, 54: e508-e511. PMID: 37842781, DOI: 10.1161/strokeaha.123.044793.Peer-Reviewed Original ResearchEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2022
Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis
Roh DJ, Asonye IS, Poyraz F, Magid-Bernstein JR, Joiner EF, Avadhani R, Awad I, Hanley DF, Ziai WC, Murthy SB. Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis. Stroke 2022, 53: 1847-1853. PMID: 35086362, PMCID: PMC9133068, DOI: 10.1161/strokeaha.121.037438.Peer-Reviewed Original ResearchConceptsCLEAR III trialVentriculoperitoneal shunt placementIntraventricular hemorrhage expansionIII trialsIVH patientsShunt placementICH locationHematoma expansionIVH expansionHemorrhage expansionSubsequent ventriculoperitoneal shunt placementGlasgow Coma Scale scoreBaseline ICH volumeClinical trial cohortComposite of deathLong-term outcomesMultivariable logistic regressionPoor functional outcomePost-hoc exploratory analysisMultivariable regression modelsIntracerebral hemorrhage volumeRandomization armAnticoagulant useTrial cohortClinical outcomes
2020
Red Blood Cell Transfusions and Outcomes After Intracerebral Hemorrhage
Roh DJ, Carvalho Poyraz F, Magid-Bernstein J, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Hod E, Murthy SB. Red Blood Cell Transfusions and Outcomes After Intracerebral Hemorrhage. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105317. PMID: 32992186, PMCID: PMC7686150, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105317.Peer-Reviewed Original ResearchConceptsRBC transfusionICH outcomeDisease severityComorbidity burdenICH hospitalizationsPoor outcomeRed blood cell transfusionICD-9-CM codesBlood cell transfusionAdditional prospective studiesRed blood cell levelsIntracerebral hemorrhage outcomesNationwide Inpatient SampleLower red blood cell levelsBlood cell levelsBaseline comorbiditiesHospital mortalityTransfusion exposureVentriculostomy drainsCell transfusionLow comorbidityIntracerebral hemorrhageMechanical ventilationProspective studyInpatient SampleA rare case of HIV CNS escape in a patient previously considered a viral controller
Magid-Bernstein J, Guo CY, Chow FC, Thakur KT. A rare case of HIV CNS escape in a patient previously considered a viral controller. International Journal Of STD & AIDS 2020, 31: 694-698. PMID: 32538333, DOI: 10.1177/0956462420922452.Peer-Reviewed Original ResearchConceptsViral controllersViral suppressionFungal CNS infectionsNon-HIV infectionsPerinatal HIV infectionHuman immunodeficiency virus ribonucleic acid levelsCentral nervous systemRibonucleic acid levelsCNS infectionsHIV RNAHIV infectionRare caseCerebrospinal fluidNervous systemAcid levelsInfectionYoung menIndependent replicationHIVPatientsSuppressionSetting
2019
Low hemoglobin and hematoma expansion after intracerebral hemorrhage.
Roh DJ, Albers DJ, Magid-Bernstein J, Doyle K, Hod E, Eisenberger A, Murthy S, Witsch J, Park S, Agarwal S, Connolly ES, Elkind MSV, Claassen J. Low hemoglobin and hematoma expansion after intracerebral hemorrhage. Neurology 2019, 93: e372-e380. PMID: 31209179, PMCID: PMC6669932, DOI: 10.1212/wnl.0000000000007820.Peer-Reviewed Original ResearchConceptsAdmission hemoglobin levelsLower admission hemoglobin levelsLower hemoglobin levelsHemoglobin levelsHematoma expansionLower hemoglobinWorse outcomesMultivariable logistic regression modelSeparate multivariable logistic regression modelsPoor clinical outcomeMeeting inclusion criteriaIntracerebral hemorrhage volumeLogistic regression modelsAdmission hemoglobinRankin ScaleCohort studyConsecutive patientsClinical outcomesIntracerebral hemorrhagePoor outcomeICH outcomeICH scoreHemorrhage volumeModifiable targetsInclusion criteria
2017
Categorization of survival and death after cardiac arrest
Matthews EA, Magid-Bernstein J, Presciutti A, Rodriguez A, Roh D, Park S, Claassen J, Agarwal S. Categorization of survival and death after cardiac arrest. Resuscitation 2017, 114: 79-82. PMID: 28279695, PMCID: PMC5548414, DOI: 10.1016/j.resuscitation.2017.03.005.Peer-Reviewed Original ResearchConceptsCerebral Performance CategoryPoor neurological prognosisNeurological prognosisFamily's wishesPoor outcomeMost cardiac arrest patientsFavorable recoveryOne-yearEarly recovery groupUnfavorable neurological prognosisCardiac arrest patientsLife-sustaining therapyHemodynamic instabilityFavorable prognosisArrest patientsCardiac arrestGOC discussionsWorse outcomesPatient outcomesBrain deathCommon causeEarly recoveryCare conversationsRecovery groupMost survivorsHuman CD39+ Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism
Magid-Bernstein JR, Rohowsky-Kochan CM. Human CD39+ Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism. Journal Of Interferon & Cytokine Research 2017, 37: 153-164. PMID: 28387597, PMCID: PMC6435349, DOI: 10.1089/jir.2016.0071.Peer-Reviewed Original ResearchConceptsIL-17STAT3-dependent mechanismIL-23RHuman CD4T effector cellsIFN-γ productionEctonucleotidase CD39Autologous CD4Regulatory cellsAutoimmune responseEffector cellsAutoimmune diseasesTranscription factor STAT3Immune responseProliferative responseCD25CD4CD39Human CD39Surface markersSTAT3 activationCCR6STAT3CellsFirst evidenceUse of early head CT following out-of-hospital cardiopulmonary arrest
Reynolds AS, Matthews E, Magid-Bernstein J, Rodriguez A, Park S, Claassen J, Agarwal S. Use of early head CT following out-of-hospital cardiopulmonary arrest. Resuscitation 2017, 113: 124-127. PMID: 28057527, PMCID: PMC5548415, DOI: 10.1016/j.resuscitation.2016.12.018.Peer-Reviewed Original ResearchConceptsEarly head CTHead CTAcute abnormalitiesCardiac arrestPremorbid statusCerebral Performance CategoryPatient's premorbid statusHospital cardiopulmonary arrestHospital cardiac arrestPost-arrest patientsPost-resuscitation managementDuration of arrestAbnormal scansCardiopulmonary arrestNeurological emergencyRetrospective studyFunctional statusNeurological abnormalitiesPatient managementPatientsAbnormalitiesPerformance categoriesFirst 24hOHCAArrest
2016
Unexpected Rapid Improvement and Neurogenic Stunned Myocardium in a Patient With Acute Motor Axonal Neuropathy
Magid-Bernstein J, Al-Mufti F, Merkler AE, Roh D, Patel S, May TL, Agarwal S, Claassen J, Park S. Unexpected Rapid Improvement and Neurogenic Stunned Myocardium in a Patient With Acute Motor Axonal Neuropathy. Journal Of Clinical Neuromuscular Disease 2016, 17: 135-141. PMID: 26905914, DOI: 10.1097/cnd.0000000000000109.Peer-Reviewed Original ResearchConceptsNeurogenic stunned myocardiumMotor axonal neuropathyStunned myocardiumAxonal neuropathyAcute motor axonal neuropathyUpper respiratory illnessBarré syndromeNeurologic symptomsAntiganglioside antibodiesComplete tetraplegiaHealthy womenRespiratory illnessLumbar punctureMotor functionPhysical therapyRare casePlasmapheresisMycoplasma pneumoniaeRapid improvementAreflexiaNeuropathyPatientsTetraplegiaMyocardiumBlood
2014
Case Report
Magid-Bernstein J, Mahajan K, Lincoln J, Ming X, Rohowsky-Kochan C. Case Report. Journal Of Child Neurology 2014, 30: 386-390. PMID: 24736120, DOI: 10.1177/0883073814529821.Peer-Reviewed Original ResearchConceptsT cellsCytokine profileInterleukin-17T cell cytokine profilesT-cell abnormalitiesT regulatory (Treg) cellsGender-matched controlsImmune alterationsRegulatory cellsDifferent comorbiditiesMultiple sclerosisCase reportNeurodevelopmental disordersMonozygotic twinsComorbiditiesInterferonAutism spectrum disorderDisordersHigh percentageSpectrum disorderCells
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