About
Specializing in Medicinal Chemistry, Drug Design, and Molecular Modeling. Committed to advancing life sciences through innovative drug development and optimizing compounds to address unmet medical needs. Passionate about collaborative research and translating discoveries into therapeutic breakthroughs.
Research
Publications
Featured Publications
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Golani LK, Wallace-Povirk A, Deis SM, Wong J, Ke J, Gu X, Raghavan S, Wilson MR, Li X, Polin L, de Waal PW, White K, Kushner J, O'Connor C, Hou Z, Xu HE, Melcher K, Dann CE 3rd, Matherly LH, Gangjee A. Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem 2016, 59: 7856-76. PMID: 27458733, DOI: 10.1021/acs.jmedchem.6b00594.Peer-Reviewed Original ResearchDesign, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.
Golani LK, Islam F, O'Connor C, Dekhne AS, Hou Z, Matherly LH, Gangjee A. Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. Bioorg Med Chem 2020, 28: 115544. PMID: 32503687, DOI: 10.1016/j.bmc.2020.115544.Peer-Reviewed Original Research8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABA(A) Receptor.
Golani LK, Platt DM, Rüedi-Bettschen D, Edwanker C, Huang S, Poe MM, Furtmüller R, Sieghart W, Cook JM, Rowlett JK. 8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABA(A) Receptor. Front Pharmacol 2021, 12: 625233. PMID: 33959005, DOI: 10.3389/fphar.2021.625233.Peer-Reviewed Original ResearchRationalizing the binding and α subtype selectivity of synthesized imidazodiazepines and benzodiazepines at GABAA receptors by using molecular docking studies.
Golani LK, Yeunus Mian M, Ahmed T, Pandey KP, Mondal P, Sharmin D, Rezvanian S, Witkin JM, Cook JM. Rationalizing the binding and α subtype selectivity of synthesized imidazodiazepines and benzodiazepines at GABAA receptors by using molecular docking studies. Bioorg Med Chem Lett 2022, 62: 128637. PMID: 35218882, DOI: 10.1016/j.bmcl.2022.128637.Peer-Reviewed Original ResearchMetabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3-selective GABAkine KRM-II-81.
Golani LK, Divović B, Sharmin D, Pandey KP, Mian MY, Cerne R, Zahn NM, Meyer MJ, Tiruveedhula VVNPB, Smith JL, Ping X, Jin X, Lippa A, Schkeryantz JM, Arnold LA, Cook JM, Savić MM, Witkin JM. Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3-selective GABAkine KRM-II-81. Biopharm Drug Dispos 2022, 43: 66-75. PMID: 35194800, DOI: 10.1002/bdd.2313.Peer-Reviewed Original ResearchStructure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter.
Golani LK, George C, Zhao S, Raghavan S, Orr S, Wallace A, Wilson MR, Hou Z, Matherly LH, Gangjee A. Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter. J Med Chem 2014, 57: 8152-66. PMID: 25234128, DOI: 10.1021/jm501113m.Peer-Reviewed Original Research
2024
Evaluation of the sedative-motor effects of novel GABAkine imidazodiazepines using quantitative observation techniques in rhesus monkeys.
Sharmin D, Rüedi-Bettschen D, Berro LF, Cook JE, Reeves-Darby JA, Pareek T, Mian MY, Rashid F, Golani L, Moreira-Junior EDC, Platt DM, Cook JM, Rowlett JK. Evaluation of the sedative-motor effects of novel GABAkine imidazodiazepines using quantitative observation techniques in rhesus monkeys. J Psychopharmacol 2024, 2698811241286760. PMID: 39385515, DOI: 10.1177/02698811241286760.Peer-Reviewed Original Research(R)-(-)-Ketamine: The Promise of a Novel Treatment for Psychiatric and Neurological Disorders.
Shafique H, Demers JC, Biesiada J, Golani LK, Cerne R, Smith JL, Szostak M, Witkin JM. (R)-(-)-Ketamine: The Promise of a Novel Treatment for Psychiatric and Neurological Disorders. Int J Mol Sci 2024, 25 PMID: 38928508, DOI: 10.3390/ijms25126804.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNew Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy.
Sharmin D, Divović B, Ping X, Cerne R, Smith JL, Rezvanian S, Mondal P, Meyer MJ, Kiley ME, Arnold LA, Mian MY, Pandey KP, Jin X, Mitrović JR, Djorović D, Lippa A, Cook JM, Golani LK, Scholze P, Savić MM, Witkin JM. New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy. ACS Chem Neurosci 2024, 15: 517-526. PMID: 38175916, DOI: 10.1021/acschemneuro.3c00555.Peer-Reviewed Original Research
2023
AMPA receptor antagonists for neurological and psychiatric disorders
Witkin, J. M.; Shafique, H.; Lippa, A.; Cerne, R.; Golani, L. K.; Smith, J. L. AMPA receptor antagonists for neurological and psychiatric disorders. In Horizons in Neuroscience Research, Costa, A., Villalba, E. Eds.; Vol. 50; 2023.Chapters
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West Campus Molecular Innovations Center
600 West Campus Drive, Rm 110B
West Haven, CT 06516