Marutpong Detarya, PhD
Postdoctoral AssociateAbout
Titles
Postdoctoral Associate
Biography
I am interested in the glycosylation and glycobiology research, especially in the regulation of protein glycosylation biosynthesis and its contribution to human diseases. My academic training and research experiences have provided me with an excellent background in multiple disciplines including biochemistry, molecular biology, cellular biology, and genetics. During my graduate studies under the supervision of Assoc. Prof. Dr. Chaisiri Wongkham, my research focuses on the effect of O-GalNAcylation, the initial sugar modification of proteins for O-like glycosylation biosynthesis inside the cells, on the progression of cholangiocarcinoma (CCA) cells. This experience deepened my knowledge in glycobiology and cancer biology. Moreover, during my Ph.D., I had the opportunity to conduct research in Assoc. Prof. Dr. Norie Araki's Lab, at Kumamoto University, Japan. I have done proteomic analysis of CCA cells and identified the GalNAcylated proteins, which related to CCA aggressiveness, using mass spectrometry. Then, I have continue worked in Prof. Dr. Sopit Wongkham's Lab to complete my Ph.D. studies. We elucidated the significance of O-GalNAcylation on epidermal growth factor receptor (EGFR) expression and function. After that, I was a research assistant at Department of Tumor Genetics and Biology, Faculty of Life Sciences, Kumamoto University, under supervision Assoc. Prof. Dr. Norie Araki. I'm have research training for cancer stem cells experiments and Mass spectrometry-base proteomics technology. During my graduate careers, I received several academic awards. In addition to furthering my research skills, I have been honing my academic performance, public-speaking, conference/lab-management, and mentoring skills, all of which will serve me well in my role as an independent investigator.
Appointments
Therapeutic Radiology
Postdoctoral AssociatePrimary
Other Departments & Organizations
- All Institutions
- Therapeutic Radiology
Education & Training
- PhD
- Khon Kaen University, Medical Biochemistry and Molecular Biology (2021)
- BSc (Hon)
- Khon Kaen University, Medical Technology (2012)
Research
Research at a Glance
Publications Timeline
Publications
2023
Induction of apoptotic cell death of cholangiocarcinoma cells by tiliacorinine from Tiliacora triandra: A mechanistic insight.
Detarya M, Mahalapbutr P, Waenphimai O, Kidoikhammouan S, Janeklang S, Sawanyawisuth K, Vaeteewoottacharn K, Seubwai W, Saengboonmee C, Thothaisong T, Pabuprapap W, Suksamrarn A, Wongkham S. Induction of apoptotic cell death of cholangiocarcinoma cells by tiliacorinine from Tiliacora triandra: A mechanistic insight. Biochim Biophys Acta Gen Subj 2023, 1867: 130486. PMID: 37813201, DOI: 10.1016/j.bbagen.2023.130486.Peer-Reviewed Original ResearchEstablishment and characterization of a novel cancer stem-like cell of cholangiocarcinoma.
Panawan O, Silsirivanit A, Chang CH, Putthisen S, Boonnate P, Yokota T, Nishisyama-Ikeda Y, Detarya M, Sawanyawisuth K, Kaewkong W, Muisuk K, Luang S, Vaeteewoottacharn K, Kariya R, Yano H, Komohara Y, Ohta K, Okada S, Wongkham S, Araki N. Establishment and characterization of a novel cancer stem-like cell of cholangiocarcinoma. Cancer Sci 2023, 114: 3230-3246. PMID: 37026527, DOI: 10.1111/cas.15812.Peer-Reviewed Original Research
2022
Low Dose Berberine Suppresses Cholangiocarcinoma Cell Progression as a Multi-Kinase Inhibitor.
Obchoei S, Detarya M, Boonnate P, Saranaruk P, Vaeteewoottacharn K, Mahalapbutr P, Okada S, Wongkham S. Low Dose Berberine Suppresses Cholangiocarcinoma Cell Progression as a Multi-Kinase Inhibitor. Asian Pac J Cancer Prev 2022, 23: 3379-3386. PMID: 36308362, DOI: 10.31557/APJCP.2022.23.10.3379.Peer-Reviewed Original ResearchEmerging roles of GALNT5 on promoting EGFR activation in cholangiocarcinoma: a mechanistic insight.
Detarya M, Lert-Itthiporn W, Mahalapbutr P, Klaewkla M, Sorin S, Sawanyawisuth K, Silsirivanit A, Seubwai W, Wongkham C, Araki N, Wongkham S. Emerging roles of GALNT5 on promoting EGFR activation in cholangiocarcinoma: a mechanistic insight. Am J Cancer Res 2022, 12: 4140-4159. PMID: 36225633.Peer-Reviewed Original ResearchLactic acidosis promotes aggressive features of cholangiocarcinoma cells via upregulating ALDH1A3 expression through EGFR axis.
Thamrongwaranggoon U, Detarya M, Seubwai W, Saengboonmee C, Hino S, Koga T, Nakao M, Wongkham S. Lactic acidosis promotes aggressive features of cholangiocarcinoma cells via upregulating ALDH1A3 expression through EGFR axis. Life Sci 2022, 302: 120648. PMID: 35598658, DOI: 10.1016/j.lfs.2022.120648.Peer-Reviewed Original ResearchHigh Glucose Induced Upregulation of Cyclin a Associating with a Short Survival of Patients with Cholangiocarcinoma: A Potential Target for Treatment of Patients with Diabetes Mellitus.
Saengboonmee C, Detarya M, Sangkhamanon S, Sawanyawisuth K, Seubwai W, Wongkham S. High Glucose Induced Upregulation of Cyclin a Associating with a Short Survival of Patients with Cholangiocarcinoma: A Potential Target for Treatment of Patients with Diabetes Mellitus. Nutr Cancer 2022, 74: 1734-1744. PMID: 34353198, DOI: 10.1080/01635581.2021.1961830.Peer-Reviewed Original Research
2021
FOXM1c is the predominant FOXM1 isoform expressed in cholangiocarcinoma that associated with metastatic potential and poor prognosis of patients.
Klinhom-On N, Seubwai W, Sawanyawisuth K, Lert-Itthiporn W, Waraasawapati S, Detarya M, Wongkham S. FOXM1c is the predominant FOXM1 isoform expressed in cholangiocarcinoma that associated with metastatic potential and poor prognosis of patients. Heliyon 2021, 7: e06846. PMID: 33997388, DOI: 10.1016/j.heliyon.2021.e06846.Peer-Reviewed Original ResearchHigh glucose upregulates FOXM1 expression via EGFR/STAT3 dependent activation to promote progression of cholangiocarcinoma.
Detarya M, Thaenkaew S, Seubwai W, Indramanee S, Phoomak C, Saengboonmee C, Wongkham S, Wongkham C. High glucose upregulates FOXM1 expression via EGFR/STAT3 dependent activation to promote progression of cholangiocarcinoma. Life Sci 2021, 271: 119114. PMID: 33513399, DOI: 10.1016/j.lfs.2021.119114.Peer-Reviewed Original Research
2020
The O-GalNAcylating enzyme GALNT5 mediates carcinogenesis and progression of cholangiocarcinoma via activation of AKT/ERK signaling.
Detarya M, Sawanyawisuth K, Aphivatanasiri C, Chuangchaiya S, Saranaruk P, Sukprasert L, Silsirivanit A, Araki N, Wongkham S, Wongkham C. The O-GalNAcylating enzyme GALNT5 mediates carcinogenesis and progression of cholangiocarcinoma via activation of AKT/ERK signaling. Glycobiology 2020, 30: 312-324. PMID: 31868214, DOI: 10.1093/glycob/cwz098.Peer-Reviewed Original Research
2019
O-GlcNAc-induced nuclear translocation of hnRNP-K is associated with progression and metastasis of cholangiocarcinoma.
Phoomak C, Park D, Silsirivanit A, Sawanyawisuth K, Vaeteewoottacharn K, Detarya M, Wongkham C, Lebrilla CB, Wongkham S. O-GlcNAc-induced nuclear translocation of hnRNP-K is associated with progression and metastasis of cholangiocarcinoma. Mol Oncol 2019, 13: 338-357. PMID: 30444036, DOI: 10.1002/1878-0261.12406.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor Outstanding Thesis Award at Doctoral Level (Health Sciences)
Regional AwardGraduate School, Khon Kaen UniversityDetails05/17/2022Thailandhonor Outstanding Oral Presentation
International AwardThe 7th International Biochemistry and Molecular Biology ConferenceDetails07/07/2021Thailandhonor Excellent Poster Presentation
International Award11th Asian Community of Glycoscience and GlycotechnologyDetails11/14/2019South Koreahonor Travel Grant Award
International AwardThe 76th Annual Meeting of the Japanese Cancer AssociationDetails09/30/2017Japanhonor Best Poster Presentation
Regional Award25 years of Medical Biochemistry and Molecular Biology ConferenceDetails08/01/2017Thailand