Meghan Van Zandt
Associate Research Scientist in PsychiatryCards
About
Research
Publications
2025
Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns
Fedorova O, Luo M, Jagdmann G, Van Zandt M, Sisto L, Pyle A. Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns. ACS Chemical Biology 2025 PMID: 39824511, DOI: 10.1021/acschembio.4c00631.Peer-Reviewed Original ResearchGroup II intronsRNA tertiary structureII intronsSelf-splicing group II intronsTertiary structureAntifungal activityDiscovery of small moleculesHigh-throughput screening effortsAntifungal efficacyHigh-affinity ligandsRNAIntronYeastEnhanced inhibitory activitySmall moleculesScreening methodologyCandidaInhibitory activityScreening effortsHuman healthActivityInhibitor classLigandStructureCompounds