Na Wang
Associate Research ScientistCards
About
Research
Publications
2024
Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance
Wang N, Zhu B, Allnutt M, Grijalva R, Zhao H, Chandra S. Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320064121. PMID: 38833477, PMCID: PMC11181078, DOI: 10.1073/pnas.2320064121.Peer-Reviewed Original ResearchConceptsSynapse maintenanceTranscriptional changesSynaptogenic adhesion moleculesGene ontology analysisKO miceKO brainMaintenance in vivoCell-cell interactionsGlial cellsSingle-nucleus transcriptomesOntology analysisCspADifferential expressionNeuron-glia interactionsAutophagy-related genesProtein AGenesCell typesNeurodegenerative diseasesInhibitory synapsesLittermate controlsSynaptic pathwaysAdhesion moleculesGlial responseSynapse
2023
cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning
Wang X, Zhou L, Dong B, Xu F, Wang D, Shen E, Cai X, Wang Y, Wang N, Ji S, Chen W, Schonewille M, Zhu J, De Zeeuw C, Shen Y. cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning. ELife 2023, 12: e80875. PMID: 37159499, PMCID: PMC10171863, DOI: 10.7554/elife.80875.Peer-Reviewed Original ResearchConceptsPresynaptic long-term potentiationSignaling cascadesPresynaptic plasticityRelease of synaptic vesiclesLong-term potentiationThreonine phosphorylationSynaptic vesiclesFunctional relevancePurkinje cell synapsesMotor behaviorPresynaptic formLearning mechanismCerebellar learning mechanismsCascadeLearningCell synapsesBasic performanceMotor learningThreonineMotor skillsSignalVesiclesEndothelin-1–Endothelin receptor B complex contributes to oligodendrocyte differentiation and myelin deficits during preterm white matter injury
Du M, Wang N, Xin X, Yan C, Gu Y, Wang L, Shen Y. Endothelin-1–Endothelin receptor B complex contributes to oligodendrocyte differentiation and myelin deficits during preterm white matter injury. Frontiers In Cell And Developmental Biology 2023, 11: 1163400. PMID: 37009471, PMCID: PMC10063893, DOI: 10.3389/fcell.2023.1163400.Peer-Reviewed Original ResearchPreterm white matter injuryWhite matter injuryEndothelin receptor BCerebral white matter injuryPrenatal brain injuryEndothelin (ET)-1Maturation of oligodendrocytesReceptor BDefective differentiationSingle-cell RNA sequencingTransplantation therapyMyelin deficitPrecursor cellsPremyelinating oligodendrocytesOligodendrocyte differentiationOligodendrocytesPretermClinical applicationDifferentiation of OPCsEndothelinTransplantationTherapyInjuryBrain injuryRNA sequencing
2022
Potassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation
Wang N, Zhou L, Shao C, Wang X, Zhang N, Ma J, Hu H, Wang Y, Qiu M, Shen Y. Potassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation. Glia 2022, 70: 2093-2107. PMID: 35775976, DOI: 10.1002/glia.24240.Peer-Reviewed Original ResearchConceptsOL precursor cellsIntracellular pHImpaired OL maturationProgressive neurological declineLoss-of-function mutationsIntracellular pH regulationSeSAME/EAST syndromeNeurological declineDemyelinating diseaseLineage cellsOPC developmentPrecursor cellsOL maturationOligodendrocyte differentiationOligodendrocytesOL developmentDown-regulationDifferentiationPH regulationCellsExpressionKCNJ10KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization
Zheng R, Du Y, Wang X, Liao T, Zhang Z, Wang N, Li X, Shen Y, Shi L, Luo J, Xia J, Wang Z, Xu J. KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. ELife 2022, 11: e72483. PMID: 35138249, PMCID: PMC8828051, DOI: 10.7554/elife.72483.Peer-Reviewed Original ResearchConceptsDynamic microtubulesFunctional plasticity of synapsesRegulate synaptic developmentConditional knockout approachFunction of KIF2CNervous systemNeuronal activity-dependent mannerPlasticity of synapsesProtein traffickingActivity-dependent mannerDepolymerizing proteinsRNAi knockdownSynaptic plasticityExpression of AMPA receptorsMicrotubule dynamicsMicrotubule invasionMicrotubule depolymerizationImpaired excitatory transmissionKnockout approachRegulatory mechanismsKIF2CDepolymerization capabilityLong-term potentiationSynaptic developmentMicrotubules
2021
Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective
Su L, Wang N, Han J, Shen Y. Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective. The Neuroscientist 2021, 28: 453-468. PMID: 34088252, PMCID: PMC9449437, DOI: 10.1177/10738584211021018.Peer-Reviewed Original ResearchConceptsGp1 mGluRsAttention-deficit hyperactivity disorderGroup 1 metabotropic glutamate receptorsGlutamate receptorsAutism spectrum disorderMetabotropic glutamate receptorsParkinson's diseaseAlzheimer's diseaseHyperactivity disorderIntellectual disabilityMultiple CNS disordersSpectrum disorderPsychiatric diseasesMGluRsCentral nervous systemSynaptic efficacyDisordersAutismRett syndromeDown syndromeCNS disordersHuntington's diseaseParkinsonAlzheimerSchizophreniaDifferent roles of Numb-p72 and Numb-p65 on the trafficking of metabotropic glutamate receptor 5
Wang N, Wang D, Hou X, Li X, Shen Y. Different roles of Numb-p72 and Numb-p65 on the trafficking of metabotropic glutamate receptor 5. Molecular Biology Reports 2021, 48: 595-600. PMID: 33394235, DOI: 10.1007/s11033-020-06103-0.Peer-Reviewed Original ResearchConceptsClathrin-coated vesiclesIsoforms of NumbHEK293T cellsMetabotropic glutamate receptor 5Receptor 5Numb isoformsGlutamate receptor 5Expression patternsMembrane expressionExpression of metabotropic glutamate receptor 5TraffickingIsoformsBinding to mGluR5Complete structureExpressionMGluR5 trafficking
2020
Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
Zhou L, Shao C, Xie Y, Wang N, Xu S, Luo B, Wu Z, Ke Y, Qiu M, Shen Y. Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination. ELife 2020, 9: e52056. PMID: 31944179, PMCID: PMC6984811, DOI: 10.7554/elife.52056.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCateninsCell DifferentiationCell LineageCentral Nervous SystemGene Expression RegulationMiceMice, KnockoutOligodendrocyte Precursor CellsOligodendrogliaPlatelet-Derived Growth FactorProtein-Tyrosine KinasesReceptors, Growth FactorRNA, Small InterferingSignal TransductionTranscription FactorsTranscriptomeConceptsPlatelet-derived growth factorCentral nervous system myelinDownstream targetsPlatelet-derived growth factor stimulationPDGF signalingPlatelet-derived growth factor signalingReceptor tyrosine kinasesAdaptor proteinCentral nervous system hypomyelinationGab1Nuclear accumulationOligodendrocyte precursor cellsTyrosine kinaseCentral nervous systemOligodendrocyte precursor cell differentiationConditional deletionOL lineage cellsOligodendrocyte differentiationDifferentiationSteady-state numberB-cateninPrecursor cellsLineage cellsTrophic supportGrowth factor
2019
Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells
Xu F, Zhou L, Wang X, Jia F, Ma K, Wang N, Lin L, Xu F, Shen Y. Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells. Nature Neuroscience 2019, 23: 1041-1043. PMID: 31570863, DOI: 10.1038/s41593-019-0475-3.Peer-Reviewed Original ResearchNumb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors
Wang N, Wang D, Shen Y. Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors. Neuroscience Letters 2019, 707: 134291. PMID: 31129078, DOI: 10.1016/j.neulet.2019.134291.Peer-Reviewed Original ResearchConceptsMembrane expressionExpression of metabotropic glutamate receptor 1Expression of metabotropic glutamate receptor 5Metabotropic glutamate receptor 1Expression of mGlu5Metabotropic glutamate receptor 5Clathrin-coated vesiclesGlutamate receptor 1Functions of NumbGlutamate receptor 5Three-chamber social testNumb deficiencyAutistic-like behaviorsTrans-membrane receptorsHomologous genesExcitatory neuronsReceptor 5MGlu5Receptor 1Impaired traffickingConditional knockoutNumbnessBrain regionsSocial testMotor coordination
Get In Touch
Contacts
Email