2019
Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors
Wang N, Wang D, Shen Y. Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors. Neuroscience Letters 2019, 707: 134291. PMID: 31129078, DOI: 10.1016/j.neulet.2019.134291.Peer-Reviewed Original ResearchConceptsMembrane expressionExpression of metabotropic glutamate receptor 1Expression of metabotropic glutamate receptor 5Metabotropic glutamate receptor 1Expression of mGlu5Metabotropic glutamate receptor 5Clathrin-coated vesiclesGlutamate receptor 1Functions of NumbGlutamate receptor 5Three-chamber social testNumb deficiencyAutistic-like behaviorsTrans-membrane receptorsHomologous genesExcitatory neuronsReceptor 5MGlu5Receptor 1Impaired traffickingConditional knockoutNumbnessBrain regionsSocial testMotor coordination
2018
Numb-p72, but not Numb-p65, contributes to the trafficking of group I metabotropic glutamate receptors
Wang N, Cai X, Gao W, Shen Y. Numb-p72, but not Numb-p65, contributes to the trafficking of group I metabotropic glutamate receptors. Neuroreport 2018, 29: 902-906. PMID: 29762249, DOI: 10.1097/wnr.0000000000001051.Peer-Reviewed Original ResearchConceptsTrafficking of transmembrane receptorsClathrin-coated vesiclesHEK293T cellsNumb isoformsTransmembrane receptorsTraffickingGroup I metabotropic glutamate receptorsMetabotropic glutamate receptor 1Glutamate receptor 1Synaptic expressionExpression of mGlu1aMembrane expressionT cellsGlutamate receptorsReceptor 1MembraneMGlu1Neuronal membranesNumb deficiencyIsoformsReceptorsHEK293ProteinNumbnessVesicles
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