2022
KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization
Zheng R, Du Y, Wang X, Liao T, Zhang Z, Wang N, Li X, Shen Y, Shi L, Luo J, Xia J, Wang Z, Xu J. KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. ELife 2022, 11: e72483. PMID: 35138249, PMCID: PMC8828051, DOI: 10.7554/elife.72483.Peer-Reviewed Original ResearchConceptsDynamic microtubulesFunctional plasticity of synapsesRegulate synaptic developmentConditional knockout approachFunction of KIF2CNervous systemNeuronal activity-dependent mannerPlasticity of synapsesProtein traffickingActivity-dependent mannerDepolymerizing proteinsRNAi knockdownSynaptic plasticityExpression of AMPA receptorsMicrotubule dynamicsMicrotubule invasionMicrotubule depolymerizationImpaired excitatory transmissionKnockout approachRegulatory mechanismsKIF2CDepolymerization capabilityLong-term potentiationSynaptic developmentMicrotubules
2018
Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy
Zhou L, Zhou L, Su L, Cao S, Xie Y, Wang N, Shao C, Wang Y, Zhou J, Cowell J, Shen Y. Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy. Journal Of Neuroscience 2018, 38: 3346-3357. PMID: 29491011, PMCID: PMC5884462, DOI: 10.1523/jneurosci.3245-17.2018.Peer-Reviewed Original ResearchConceptsLeucine-rich glioma-inactivated 1Autosomal dominant lateral temporal epilepsyIntrinsic excitability of pyramidal neuronsExcitability of pyramidal neuronsGlioma-inactivated 1Seizure susceptibilityPyramidal neuronsIntrinsic excitabilityLateral temporal epilepsyGlutamatergic transmissionInherited syndromeTemporal epilepsyNonsynaptic epileptiform activityCytosolic phospholipase A<sub>2</sub>Nonsteroidal anti-inflammatory drugsCortical pyramidal neuronsAnti-inflammatory drugsKv1.2 expressionEpileptiform activityMutant miceFDA-approved drugsPathogenic basisCOX2 inhibitionCortical neuronsCelecoxib
2012
AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic β Cells
Wu Z, Zhu L, Zou N, Bombek L, Shao C, Wang N, Wang X, Liang L, Xia J, Rupnik M, Shen Y. AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic β Cells. Traffic 2012, 13: 1124-1139. PMID: 22540213, DOI: 10.1111/j.1600-0854.2012.01373.x.Peer-Reviewed Original ResearchConceptsK(ATP) channelsGlutamate applicationB cellsInsulin releaseA-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorIonotropic glutamate receptorsKnock-out miceDepolarization-induced exocytosisMouse B cellsInsulin-containing granulesPancreatic B-cellsGlutamate receptorsCytosolic calciumCytosolic cGMPAMPARAcid receptorsInsulin secretionInsulinoma cellsInsulinGlutamateMiceReceptorsExocytosisIGluRsRelease
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply