Interventional antibiotic treatment replacing antibiotic prophylaxis during allogeneic hematopoietic stem cell transplantation is safe and leads to a reduction of antibiotic administration
Toenges R, Lang F, Ghaffar R, Lindner S, Schlipfenbacher V, Riemann J, Ajib S, Kouidri K, Cremer A, Weber B, Nguyen N, Knoch A, Vehreschild J, Serve H, Bug G. Interventional antibiotic treatment replacing antibiotic prophylaxis during allogeneic hematopoietic stem cell transplantation is safe and leads to a reduction of antibiotic administration. Annals Of Hematology 2024, 103: 4687-4699. PMID: 39237814, DOI: 10.1007/s00277-024-05986-4.Peer-Reviewed Original ResearchGraft-versus-host diseaseSystemic antibiotic prophylaxisNon-relapse mortalityChronic graft-versus-host diseaseAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationStem cell transplantationClostridium difficile infectionAntibiotic prophylaxisOverall survivalCumulative incidenceBloodstream infectionsCell transplantationAntibiotic treatmentCumulative incidence of acute GVHD grades II-IVSevere chronic graft-versus-host diseaseRisk of graft-versus-host diseaseAcute GVHD grade II-IVGVHD grade II-IVDuration of antibiotic therapyRisk of infection-related mortalityPre-engraftment periodGrade II-IVMedian follow-upInfection-related mortality
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