Nils Petersen, MD, PhD, MSc
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Staff Neurointensivist, Neuroscience Intensive Care Unit
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Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Staff Neurointensivist, Neuroscience Intensive Care Unit
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Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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Staff Neurointensivist, Neuroscience Intensive Care Unit
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About
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Titles
Associate Professor Term
Staff Neurointensivist, Neuroscience Intensive Care Unit
Biography
Nils Petersen obtained his medical degree and a doctorate in neuroscience from Christian-Albrechts University in Kiel, Germany. He completed his residency in Neurology at Mount Sinai Hospital in New York, NY, where he also served as chief resident in his final year. He then pursued fellowship training in Vascular Neurology at Columbia University and simultaneously completed a Master's degree in Patient-Oriented Research at the Mailman School of Public Health. He next completed a fellowship in Neurocritical Care at Massachusetts General Hospital and also obtained certification in Neurovascular Ultrasound from the American Society of Neuroimaging.
He is the director of the Yale Cerebral Blood Flow Laboratory, which provides the infrastructure for advanced monitoring of brain physiology. His clinical and research interests are in using ultrasound and novel neuromonitoring modalities to better understand brain blood flow regulation. His ongoing clinical care of patients in the Neurologic Intensive Care Unit and Stroke Service continues to inspire his research pursuits, with the goal of improving patient outcomes and preventing neurologic worsening after acute ischemic stroke.
Appointments
Neurology
Associate Professor on TermPrimary
Other Departments & Organizations
- All Institutions
- Center for Neuroepidemiology and Clinical Neurological Research
- Janeway Society
- Neurocritical Care & Emergency Surgery
- Neurology
- Petersen Lab
- Stroke Center
- Stroke Telemedicine Program
- Vascular Neurology
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Fellowship
- Massachusetts General Hospital/Brigham and Women's Hospital (2014)
- Fellowship
- Massachusetts General Hospital (2014)
- MSc
- Mailman School of Public Health, Columbia University (2013)
- Fellowship
- Columbia University/New York Presbyterian (2012)
- Fellowship
- Columbia University (2012)
- Residency
- Mount Sinai Medical Center (2010)
- Residency
- Mount Sinai Hospital (2010)
- Residency
- University Hospital Schleswig-Holstein (2006)
- PhD
- Christian-Albrechts-University (2004)
- MD
- Christian-Albrechts-University (2004)
Research
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Overview
Medical Research Interests
ORCID
0000-0001-9711-3340- View Lab Website
Petersen Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Kevin Sheth, MD, FAHA
Charles Matouk, MD
Guido J. Falcone, MD, ScD, MPH
Adam de Havenon, MD, MSCI
Lauren Hachmann Sansing, MD, MS, FAHA, FANA
Emily J. Gilmore, MD, FNCS, FACNS
Publications
2025
Different Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage
Clocchiatti-Tuozzo S, Rivier C, Qureshi A, Renedo D, Huo S, Matouk C, Petersen N, de Havenon A, Sheth K, Rabinstein A, Falcone G, Hawkes M. Different Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage. Neurocritical Care 2025, 1-9. PMID: 40293696, DOI: 10.1007/s12028-025-02269-2.Peer-Reviewed Original ResearchAltmetricConceptsRenal adverse eventsDeep intracerebral hemorrhageIntensive BP reductionRisk of renal adverse eventsRisk of HEHematoma expansionBP reductionATACH-2Intracerebral hemorrhageLobar intracerebral hemorrhageFunctional outcomesAntihypertensive Treatment of Acute Cerebral Hemorrhage IIAcute spontaneous intracerebral hemorrhageAcute intracerebral hemorrhageSpontaneous intracerebral hemorrhageAssociated with reduced riskUnfavorable functional outcomeBlood pressure reductionRandomized clinical trialsMultivariate logistic regression resultsPost Hoc AnalysisAntihypertensive treatmentAdverse eventsClinical trialsIncreased riskPolygenic Resistance to Vascular Risk Factor Control in Stroke Survivors (S30.006)
Huo S, Rivier C, Clocchiatti-Tuozzo S, Renedo D, Torres-Lopez V, Sunmonu N, Petersen N, De Havenon A, Sheth K, Falcone G. Polygenic Resistance to Vascular Risk Factor Control in Stroke Survivors (S30.006). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000208802.Peer-Reviewed Original ResearchAltmetricEnhancing Autoregulation-guided Blood Pressure Management after Large-vessel Ischemic Stroke (P9-13.010)
Thinzar P, Jayasundara S, Estrella D, Stoehr K, Gutierrez S, Petersen N. Enhancing Autoregulation-guided Blood Pressure Management after Large-vessel Ischemic Stroke (P9-13.010). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000211008.Peer-Reviewed Original ResearchBlood Pressure Variability as a Marker of Sympathetic Hyperreactivity in Postpartum Patients with Preeclampsia, with and without Chronic Hypertension (P2-7.003)
Kirschner M, Martinez H, Taliadouros L, Haghighi N, Castro P, Booker W, Bello N, Petersen N, Miller E. Blood Pressure Variability as a Marker of Sympathetic Hyperreactivity in Postpartum Patients with Preeclampsia, with and without Chronic Hypertension (P2-7.003). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000211236.Peer-Reviewed Original ResearchElevated Pre-hospital Blood Pressure is Associated with Reduced Infarct Volume in Large Vessel Occlusion Ischemic Strokes (P12-13.016)
Galecio-Castillo M, Shogren S, Olexa M, Begunova Y, Cruz L, Kalakoti P, Brito-Alvarado A, Petersen N, Gutierrez S. Elevated Pre-hospital Blood Pressure is Associated with Reduced Infarct Volume in Large Vessel Occlusion Ischemic Strokes (P12-13.016). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000212687.Peer-Reviewed Original Research
2024
Continuous versus Intermittent Blood Pressure Monitoring in Postpartum Preeclampsia with Severe Features
Martinez H, Haghighi N, van Wingerden A, Kirschner M, Booker W, Bello N, Petersen N, Miller E. Continuous versus Intermittent Blood Pressure Monitoring in Postpartum Preeclampsia with Severe Features. American Journal Of Perinatology 2024 PMID: 39486401, PMCID: PMC12103628, DOI: 10.1055/a-2457-2781.Peer-Reviewed Original ResearchAltmetricConceptsPostpartum patientsBlood pressureProportion of patientsSevere featuresBlood pressure monitoringIntermittent monitoringPostpartum preeclampsiaPaired t-testArterial pressureFinger plethysmographyPreeclampsiaBP measurement methodsClinical protocolsMcNemar testBP valuesBP monitoringBrachial BPPatientsPressure monitoringBP measurementsOscillometric devicePostpartumMmHgT-testSBPEndovascular Treatment of Patients With Acute Ischemic Stroke With Tandem Lesions Presenting With Low Alberta Stroke Program Early Computed Tomography Score
Galecio-Castillo M, Farooqui M, Guerrero W, Ribo M, Hassan A, Jumaa M, Divani A, Abraham M, Petersen N, Fifi J, Malik A, Siegler J, Nguyen T, Sheth S, Linares G, Janjua N, Soomro J, Quispe-Orozco D, Olivé-Gadea M, Tekle W, Zaidi S, Sabbagh S, Barkley T, Prasad A, De Leacy R, Abdalkader M, Salazar-Marioni S, Gordon W, Turabova C, Rodriguez-Calienes A, Dibas M, Mokin M, Yavagal D, Yoo A, Sarraj A, Jovin T, Ortega-Gutierrez S. Endovascular Treatment of Patients With Acute Ischemic Stroke With Tandem Lesions Presenting With Low Alberta Stroke Program Early Computed Tomography Score. Journal Of The American Heart Association 2024, 13: e035977. PMID: 39508172, PMCID: PMC11681390, DOI: 10.1161/jaha.124.035977.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLower Alberta Stroke Program Early Computed Tomography ScoreAlberta Stroke Program Early Computed Tomography ScoreModified Rankin ScaleComputed tomography scoreSymptomatic intracranial hemorrhageEndovascular thrombectomyIntracranial hemorrhageTandem lesionsBaseline Alberta Stroke Program Early Computed Tomography ScoreAnterior circulation tandem lesionsModified Rankin Scale shiftModified Rankin Scale 0 to 2Score 0 to 2Safety of endovascular thrombectomySymptomatic intracranial hemorrhage riskOdds of symptomatic intracranial hemorrhageEndovascular treatment of patientsAcute large-vessel occlusionInternal carotid artery stenosis/occlusionIntracranial hemorrhage riskRetrospective analysis of dataProportion of patientsTreatment of patientsOrdinal modified Rankin ScaleAssociated with reduced oddsPostpartum Blood Pressure Variability and Heart Rate Variability in Preeclampsia
van Wingerden A, Katsidoniotaki M, Haghighi N, Almonte C, Martinez H, Valdes E, Castro P, Alian A, Booker W, Bello N, Marshall R, Kougioumtzoglou I, Petersen N, Miller E. Postpartum Blood Pressure Variability and Heart Rate Variability in Preeclampsia. Hypertension 2024, 81: 2510-2519. PMID: 39403810, PMCID: PMC11578794, DOI: 10.1161/hypertensionaha.124.23321.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBlood pressure variabilityChronic hypertensionHeart rate variabilitySuperimposed preeclampsiaBlood pressurePressure variabilityProspective cohort of womenTime-domain heart rate variabilityAssociated with autonomic dysregulationCohort of womenRatio of heart rate variabilityHigh blood pressure variabilityRate variabilityPreeclampsia groupLow-/high-frequency ratioPostpartum patientsPostpartum controlsPreeclampsiaRR interval differencesProspective cohortHigh-frequency heart rate variabilityAutonomic dysregulationPostpartum womenFinger plethysmographyWeeks postpartumMediation Analysis of Acute Carotid Stenting in Tandem Lesions
Rodriguez Calienes A, Galecio-Castillo M, Petersen N, Ribo M, Farooqui M, Hassan A, Jumaa M, Divani A, Abraham M, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Lu Y, Vivanco-Suarez J, Dibas M, Mokin M, Yavagal D, Jovin T, Ortega-Gutierrez S. Mediation Analysis of Acute Carotid Stenting in Tandem Lesions. Neurology 2024, 103: e209617. PMID: 38959444, DOI: 10.1212/wnl.0000000000209617.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute carotid artery stentingCarotid artery stentingEndovascular therapyNon-CA groupFunctional outcomesTandem lesionsAnterior circulation tandem lesionsTreated with endovascular therapyMulticenter retrospective cohort studyCarotid artery stenting groupAssociated with better functional outcomesFavorable functional outcomeAcute carotid stentingRetrospective cohort studyAssociated with functional outcomePredictor of functional outcomeCervical lesionsMedian ageModified thrombolysisReperfusion rateCohort studyPathophysiological mechanismsArtery stentingCarotid stentingReperfusionCervical Dissection in Patients With Tandem Lesions Is Associated With Distal Embolism and Lower Recanalization Success
Galecio-Castillo M, Guerrero W, Hassan A, Farooqui M, Jumaa M, Divani A, Abraham M, Petersen N, Fifi J, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Olivé-Gadea M, Tekle W, Zaidi S, Sabbagh S, Barkley T, Prasad A, De Leacy R, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Turabova C, Rodriguez-Calienes A, Dibas M, Mokin M, Yavagal D, Ribo M, Jovin T, Ortega-Gutierrez S. Cervical Dissection in Patients With Tandem Lesions Is Associated With Distal Embolism and Lower Recanalization Success. Stroke 2024, 55: 1808-1817. PMID: 38913799, DOI: 10.1161/strokeaha.123.046148.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInternal carotid arteryCervical internal carotid arteryDistal embolizationModified thrombolysisTandem lesionsMulticenter retrospective cohort studyParenchymal hematoma type 2Internal carotid artery stenosis/occlusionModified Rankin Scale scoreSymptomatic intracranial hemorrhageInverse probability of treatment weightingCerebral Infarction scoreCervical ICA dissectionRetrospective cohort studyProbability of treatment weightingRankin Scale scoreAssociated with higher ratesFunctional independenceRates of hypertensionAssociated with distal embolizationSelf-expanding stentsDissection etiologyRisk of distal embolizationICA occlusionCervical dissection
Clinical Trials
Current Trials
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)
HIC ID2000031893RoleSub InvestigatorPrimary Completion Date03/07/2028Recruiting ParticipantsGenderBothAge30 years - 80 yearsBlood PREssure Augmentation in Large-vessel Occlusion Stroke Study (PRESS)
HIC ID2000022525RolePrincipal InvestigatorPrimary Completion Date04/30/2019Recruiting ParticipantsGenderBothAge18+ yearsBrain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)
HIC ID2000024956RoleSub InvestigatorPrimary Completion Date07/01/2023Recruiting ParticipantsGenderBothAge14+ yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
HIC ID2000026409RoleSub InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsGenderBothAge18+ yearsTransforming Acute Stroke Detection through Real Time Neurological Monitoring
HIC ID1605017863RoleSub InvestigatorPrimary Completion Date07/01/2017Recruiting ParticipantsGenderBothAge18+ years
Clinical Care
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Overview
Nils Petersen, MD, PhD, is a neurointensivist in the neuroscience intensive care unit (NICU) of Yale New Haven Hospital. He treats life-threatening diseases that involve the brain, spinal cord and nerves, from stroke to central nervous system infections, neuromuscular diseases and neurosurgical post-operative care. “To be a skilled neurologist requires not only knowledge of how the brain works and the latest treatments,” he says, “but also the clinical acumen to pick up subtle exam findings, interpret complicated histories and apply critical thinking skills to compose the best treatment plan for each patient.”
He was recruited by Yale in 2014 to design and implement a state-of-the-art neurovascular ultrasound lab. “Hospitalization after stroke or in the NICU represents an important and vulnerable time for both patients and families, a time during which physicians have the most impact,” he says. “I feel privileged to be a part of this journey for my patients and their families, a journey that continues to inspire me both personally and scientifically on a regular basis.”
An assistant professor at Yale School of Medicine, Dr. Petersen hopes his research on brain blood flow and how it is affected by neurologic injury, particularly stroke, will help doctors improve functional outcomes after stroke.
Clinical Specialties
Fact Sheets
Ischemic Stroke
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