2020
Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells
De La Cena K, Ho R, Amraei R, Woolf N, Tashjian J, Zhao Q, Richards S, Walker J, Huang J, Chitalia V, Rahimi N. Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells. American Journal Of Pathology 2020, 191: 157-167. PMID: 33129760, PMCID: PMC7788663, DOI: 10.1016/j.ajpath.2020.09.015.Peer-Reviewed Original ResearchConceptsCell cycleColorectal cancerCell cycle checkpoint arrestCell cycle inhibitor proteinsNovel tumor suppressor geneFull molecular mechanismsPutative tumor suppressorColon cancer cellsTumor suppressor geneG2/M phaseSporadic human colorectal cancerNormal intestinal epithelial cellsEpigenetic mechanismsCheckpoint arrestTMIGD1Inhibitor proteinNovel potential therapeutic targetIntestinal epithelial cellsMolecular mechanismsTumor suppressorPoor overall survivalSuppressor geneDevelopment of adenomasImmunoglobulin domainHuman colorectal cancer
2019
c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth
Lyle C, Richards S, Yasuda K, Napoleon M, Walker J, Arinze N, Belghasem M, Vellard I, Yin W, Ravid J, Zavaro E, Amraei R, Francis J, Phatak U, Rifkin I, Rahimi N, Chitalia V. c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth. Scientific Reports 2019, 9: 20257. PMID: 31882749, PMCID: PMC6934810, DOI: 10.1038/s41598-019-56208-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesColorectal NeoplasmsGene Expression Regulation, NeoplasticHumansMacrophagesMice, KnockoutPhosphorylationProgrammed Cell Death 1 ReceptorProteasome Endopeptidase ComplexProto-Oncogene Proteins c-cblTumor BurdenTumor MicroenvironmentUbiquitin-Protein LigasesUbiquitinationConceptsPD-1Immune cellsTumor microenvironmentColorectal cancerCell death 1 proteinPD-1 regulationDeath 1 proteinImmune checkpoint receptorsColorectal tumor growthC-CblCasitas B lymphomaCRC xenograftsImmune checkpointsCheckpoint receptorsAutoimmune diseasesT lymphocytesTumor suppressive activitySuppressive activityTumor phagocytosisTumor growthFinger functionB lymphomaHigh expressionMiceXenografts
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