Gene expression in the primate orbitofrontal cortex related to anxious temperament
Kenwood M, Souaiaia T, Kovner R, Fox A, French D, Oler J, Roseboom P, Riedel M, Mueller S, Kalin N. Gene expression in the primate orbitofrontal cortex related to anxious temperament. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2305775120. PMID: 38011550, PMCID: PMC10710052, DOI: 10.1073/pnas.2305775120.Peer-Reviewed Original ResearchConceptsStress-related psychopathologyAnxiety disordersAnxious temperamentPsychiatric disordersBehavioral inhibitionOrbitofrontal cortexAnxiety-related brain regionsPrevalent psychiatric disordersIndividual differencesPrimate orbitofrontal cortexLaser capture microdissectionGlucocorticoid signalingEarly riskTreatment targetsAnxiety-related temperamentBrain regionsSubcortical structuresPrefrontal cortexTranslational modelSignificant sufferingDisordersCortexCapture microdissection
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