Shannon Sweeney
Staff Affiliate - YNHHCards
About
Research
Publications
2024
Estimating the health and macroeconomic burdens of tuberculosis in India, 2021–2040: A fully integrated modelling study
Keogh-Brown M, Sumner T, Sweeney S, Vassall A, Jensen H. Estimating the health and macroeconomic burdens of tuberculosis in India, 2021–2040: A fully integrated modelling study. PLOS Medicine 2024, 21: e1004491. PMID: 39666614, PMCID: PMC11637336, DOI: 10.1371/journal.pmed.1004491.Peer-Reviewed Original ResearchConceptsGross domestic productMacroeconomic burdenCumulative gross domestic productReturn to investmentHigh-income householdsLow-income householdsDomestic productEconomic growthReduction targetsIndian economyEconomic gainsInvestmentEconomic impactEconomyCountriesHouseholdsBurden of TBEconomic burdenDisease burdenFundingImpact of TBLarge healthCase detectionTB-related deathsProvisionImproving hospital-based opioid substitution therapy (iHOST): protocol for a mixed-methods evaluation
Lewer D, Brown M, Burns A, Eastwood N, Gittins R, Holland A, Hope V, Ko A, Lewthwaite P, Morris A, Noctor A, Preston A, Scott J, Smith E, Sweeney S, Tilouche N, Wickremsinhe M, Harris M. Improving hospital-based opioid substitution therapy (iHOST): protocol for a mixed-methods evaluation. NIHR Open Research 2024, 4: 10. PMID: 39568556, PMCID: PMC11576563, DOI: 10.3310/nihropenres.13534.2.Peer-Reviewed Original ResearchOpioid substitution therapyProcess evaluationPatient-directed dischargeAssociated with improved healthQualitative process evaluationHospital-based servicesHealth research projectsMixed-methods evaluationQuasi-experimental quantitative studyDifference-in-differences analysisMixed-methods studyOnline training moduleSubstitution therapyAdmitted to hospitalControl hospitalsAcute hospitalsImprove careOpioid withdrawalHospital cliniciansEmergency readmissionIllicit opioidsHospital staffQuantitative studyFocus groupsClinical guidelinesAfrica Health Research Institute (AHRI) Household Contact study: a study protocol, statistical analysis and modelling plan
Khan P, Govender I, McCreesh N, Sweeney S, Sithole M, Ording-Jespersen G, Buthelezi X, Houben R, Baisley K, Smit T, Wong E, Hanekom W, White R, Vassall A, Fielding K, Grant A. Africa Health Research Institute (AHRI) Household Contact study: a study protocol, statistical analysis and modelling plan. Wellcome Open Research 2024, 9: 622. DOI: 10.12688/wellcomeopenres.22974.1.Peer-Reviewed Original ResearchAfrica Health Research InstituteQuantiFERON-TB Gold PlusHealth systemAntiretroviral treatmentReport symptomsCost-effectiveness of interventionsAntiretroviral treatment careRoutine health servicesDemographic surveillance areaTuberculosis case findingHealth Research InstituteM. tuberculosis transmissionChild household contactsPotential epidemiological impactTuberculosis screening strategiesHealthcare utilisationHIV testingHealth facilitiesPulmonary tuberculosisHealth servicesSymptom screeningCase findingCost-effectiveTuberculosis screeningEffects of antiretroviral treatmentUncertainty in tuberculosis clinical decision-making: An umbrella review with systematic methods and thematic analysis
Basile F, Sweeney S, Singh M, Bijker E, Cohen T, Menzies N, Vassall A, Indravudh P. Uncertainty in tuberculosis clinical decision-making: An umbrella review with systematic methods and thematic analysis. PLOS Global Public Health 2024, 4: e0003429. PMID: 39042611, PMCID: PMC11265660, DOI: 10.1371/journal.pgph.0003429.Peer-Reviewed Original ResearchUmbrella reviewClinical decision-makingHealthcare system levelQualitative evidence synthesisBarriers to treatmentScarcity of healthcare resourcesTuberculosis knowledgeClinicians' attitudesCommon barriersResource-limited settingsHealth careHealthcare settingsClinical encountersEvidence synthesisInfluence clinical decisionsThematic analysisHealthcare resourcesDiagnostic test characteristicsStudy designSystematic reviewMeta-analysesNegative test resultsMulti-level modelProvidersDecision-makingUnit costs and cost-effectiveness of a device to improve TB treatment adherence in China
Sweeney S, Fielding K, Liu X, Thompson J, Dong H, Jiang S, Zhao Y, Huan S, Vassall A. Unit costs and cost-effectiveness of a device to improve TB treatment adherence in China. IJTLD OPEN 2024, 1: 299-305. PMID: 39035432, PMCID: PMC11257087, DOI: 10.5588/ijtldopen.23.0451.Peer-Reviewed Original ResearchIntervention cost-effectivenessHealth facility levelIncremental cost-effectiveness ratioProbabilistic sensitivity analysesTB treatment adherenceCluster-randomised superiority trialImprove treatment outcomesIncremental cost-effectivenessCost-effectiveness ratioIncremental costCost-effectiveDiscount rateUnit cost dataTreatment adherenceFacility levelLack of evidenceTreatment outcomesImprove adherenceDigital adherence technologiesEnhance patient managementScenario analysisSocietal perspectiveSuperiority trialStandard of careAdherence technologiesEconomic implications of novel regimens for tuberculosis treatment in three high-burden countries: a modelling analysis
Ryckman T, Schumacher S, Lienhardt C, Sweeney S, Dowdy D, Mirzayev F, Kendall E. Economic implications of novel regimens for tuberculosis treatment in three high-burden countries: a modelling analysis. The Lancet Global Health 2024, 12: e995-e1004. PMID: 38762299, PMCID: PMC11126367, DOI: 10.1016/s2214-109x(24)00088-3.Peer-Reviewed Original ResearchConceptsRifampin-resistant tuberculosisRifampin-susceptible tuberculosisMedium-term costsTuberculosis treatmentRifampin susceptibilityTuberculosis regimensStandard-of-care regimensCost-effective priceEstimated pricePrice thresholdsPriceDrug costsCost-neutralNovel drug combinationsStandard-of-careSouth AfricaTuberculosis treatment regimensEconomic implicationsStandard of carePatient-borne costsHigh-burden countriesCohort of adultsDecision-analytic modelShorter regimensNovel regimensImpact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis in Moldova: A mathematical modeling analysis.
James L, Klaassen F, Sweeney S, Furin J, Franke M, Yaesoubi R, Chesov D, Ciobanu N, Codreanu A, Crudu V, Cohen T, Menzies N. Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis in Moldova: A mathematical modeling analysis. PLOS Medicine 2024, 21: e1004401. PMID: 38701084, PMCID: PMC11101189, DOI: 10.1371/journal.pmed.1004401.Peer-Reviewed Original ResearchQuality-adjusted life yearsStandard of careDrug susceptibility testingRifampicin-resistant tuberculosisRR-TBEnd-of-treatmentLonger regimensTreatment strategiesTreatment outcomesBurden of drug-resistant TBCost-effective treatment strategyResistance to amikacinDrug-resistant TBSevere adverse eventsHistory of TBResistance to delamanidTB drug resistanceAnti-TB drugsLifetime costsAssociated treatment outcomesFQ-R.Average timeNatural history of TBFluoroquinolone resistanceFQ-RImproving hospital-based opioid substitution therapy (iHOST): protocol for a mixed-methods evaluation
Lewer D, Brown M, Burns A, Eastwood N, Gittens R, Holland A, Hope V, Ko A, Lewthwaite P, Morris A, Noctor A, Preston A, Scott J, Smith E, Sweeney S, Tilouche N, Wickremsinhe M, Harris M. Improving hospital-based opioid substitution therapy (iHOST): protocol for a mixed-methods evaluation. NIHR Open Research 2024, 4: 10. DOI: 10.3310/nihropenres.13534.1.Peer-Reviewed Original ResearchOpioid substitution therapyProcess evaluationMedical adviceAssociated with improved healthQualitative process evaluationHospital-based servicesHealth research projectsMixed-methods evaluationQuasi-experimental quantitative studyDifference-in-differences analysisMixed-methods studyOnline training moduleAdmitted to hospitalControl hospitalsAcute hospitalsImprove careHospital cliniciansEmergency readmissionIllicit opioidsHospital staffQuantitative studyFocus groupsClinical guidelinesSubstitution therapyPrimary outcomeSafe inhalation pipe provision (SIPP): protocol for a mixed-method evaluation of an intervention to improve health outcomes and service engagement among people who use crack cocaine in England
Harris M, Scott J, Hope V, Busza J, Sweeney S, Preston A, Southwell M, Eastwood N, Vuckovic C, McGaff C, Yoon I, Wilkins L, Ram S, Lord C, Bonnet P, Furlong P, Simpson N, Slater H, Platt L. Safe inhalation pipe provision (SIPP): protocol for a mixed-method evaluation of an intervention to improve health outcomes and service engagement among people who use crack cocaine in England. Harm Reduction Journal 2024, 21: 19. PMID: 38263202, PMCID: PMC10804795, DOI: 10.1186/s12954-024-00938-7.Peer-Reviewed Original ResearchConceptsHealth harmsMixed-methods process evaluationService engagementProcess evaluation interviewsDrug servicesImprove health outcomesMixed-methods evaluationPost-intervention surveysSmoking equipmentHealth risk awarenessParticipant eligibility criteriaImprove service accessReduction service provisionSpecialist drug servicesHarm reduction service provisionAssociated health harmsPrimary outcome measurePipe sharingCrack cocaineProcess evaluationHealth outcomesTraining interventionUnderserved populationsService accessRespiratory harm
2023
A Scoping Review and Taxonomy of Epidemiological-Macroeconomic Models of COVID-19
Bonnet G, Pearson C, Torres-Rueda S, Ruiz F, Lines J, Jit M, Vassall A, Sweeney S. A Scoping Review and Taxonomy of Epidemiological-Macroeconomic Models of COVID-19. Value In Health 2023, 27: 104-116. PMID: 37913921, DOI: 10.1016/j.jval.2023.10.008.Peer-Reviewed Original ResearchConceptsMacroeconomic projectionsTotal gross domestic productComputable general equilibriumLong-run impactsGross domestic productInput-output modelMacroeconomic impactMacroeconomic outcomesAgent-based modelAggregate consumptionGeneral equilibriumHigh-income countriesDomestic productCountry applicationsMaximization modelMitigation policiesPolicy makersPovertyEpidemiological modelModel methodologyEmpirical dataImpact of lockdownEconomistsCOVID-19 pandemicImpact