GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical Malformation
Trotter S, Kapur J, Anzivino M, Lee K. GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical Malformation. Journal Of Neuroscience 2006, 26: 10756-10767. PMID: 17050714, PMCID: PMC6674751, DOI: 10.1523/jneurosci.2323-06.2006.Peer-Reviewed Original ResearchConceptsSpontaneous IPSCsSeizure onsetCortical malformationsPyramidal neuronsAmplitude of spontaneous IPSCsFrequency of spontaneous IPSCsCalcium-binding protein parvalbuminGABAergic synaptic inhibitionHeightened seizure susceptibilityInhibitory GABAergic neurotransmissionPresynaptic GABAergic terminalsGABAergic synaptic transmissionResting membrane potentialPyramidal cell somataHigher input resistanceTish cortexMiniature IPSCsNeocortical malformationsSynaptic inhibitionGABAergic interneuronsGABAergic neurotransmissionSeizure susceptibilityProtein parvalbuminImmunohistochemical assessmentGABAergic terminals
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply