About
Titles
Associate Research Scientist
Appointments
Neuroscience
Associate Research ScientistPrimary
Other Departments & Organizations
- All Institutions
- Neuroscience
Education & Training
- Special Postdoctoral Researcher
- RIKEN Center for Brain Science (2024)
- Research Scientist
- RIKEN Center for Brain Science (2024)
- Postdoctoral Researcher
- Juntendo University Graduate School of Medicine (2021)
- PhD
- The University of Tokyo, Department of Life Sciences, Graduate School of Arts and Sciences (2020)
- MS
- The University of Tokyo, Department of Life Sciences, Graduate School of Arts and Sciences (2017)
- BS
- The University of Tokyo, Department of Integrated Science, College of Arts and Science (2015)
Research
Research at a Glance
Publications Timeline
A big-picture view of Takumi Nakamura's research output by year.
12Publications
Publications
2024
Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor.
Nakamura T, Yoshihara T, Tanegashima C, Kadota M, Kobayashi Y, Honda K, Ishiwata M, Ueda J, Hara T, Nakanishi M, Takumi T, Itohara S, Kuraku S, Asano M, Kasahara T, Nakajima K, Tsuboi T, Takata A, Kato T. Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor. Mol Psychiatry 2024, 29: 2888-2904. PMID: 38528071, DOI: 10.1038/s41380-024-02479-8.Peer-Reviewed Original ResearchTopologically associating domains define the impact of de novo promoter variants on autism spectrum disorder risk.
Nakamura T, Ueda J, Mizuno S, Honda K, Kazuno AA, Yamamoto H, Hara T, Takata A. Topologically associating domains define the impact of de novo promoter variants on autism spectrum disorder risk. Cell Genom 2024, 4: 100488. PMID: 38280381, DOI: 10.1016/j.xgen.2024.100488.Peer-Reviewed Original Research
2023
GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice.
Yamamoto H, Lee-Okada HC, Ikeda M, Nakamura T, Saito T, Takata A, Yokomizo T, Iwata N, Kato T, Kasahara T. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Mol Psychiatry 2023, 28: 2848-2856. PMID: 36806390, DOI: 10.1038/s41380-023-01988-2.Peer-Reviewed Original ResearchThe molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research.
Nakamura T, Takata A. The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research. Mol Psychiatry 2023, 28: 1868-1889. PMID: 36878965, DOI: 10.1038/s41380-023-02005-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder.
Nakamura T, Nakajima K, Kobayashi Y, Itohara S, Kasahara T, Tsuboi T, Kato T. Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder. Hum Mol Genet 2021, 30: 1851-1862. PMID: 34100076, DOI: 10.1093/hmg/ddab152.Peer-Reviewed Original ResearchSystematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder.
Nishioka M, Kazuno AA, Nakamura T, Sakai N, Hayama T, Fujii K, Matsuo K, Komori A, Ishiwata M, Watanabe Y, Oka T, Matoba N, Kataoka M, Alkanaq AN, Hamanaka K, Tsuboi T, Sengoku T, Ogata K, Iwata N, Ikeda M, Matsumoto N, Kato T, Takata A. Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder. Nat Commun 2021, 12: 3750. PMID: 34145229, DOI: 10.1038/s41467-021-23453-w.Peer-Reviewed Original Research
2020
Glutamine-induced signaling pathways via amino acid receptors in enteroendocrine L cell lines.
Nakamura T, Harada K, Kamiya T, Takizawa M, Küppers J, Nakajima K, Gütschow M, Kitaguchi T, Ohta K, Kato T, Tsuboi T. Glutamine-induced signaling pathways via amino acid receptors in enteroendocrine L cell lines. J Mol Endocrinol 2020, 64: 133-143. PMID: 31940281, DOI: 10.1530/JME-19-0260.Peer-Reviewed Original Research
2018
De novo UNC13B mutation identified in a bipolar disorder patient increases a rare exon-skipping variant.
Nakamura T, Jimbo K, Nakajima K, Tsuboi T, Kato T. De novo UNC13B mutation identified in a bipolar disorder patient increases a rare exon-skipping variant. Neuropsychopharmacol Rep 2018, 38: 210-213. PMID: 30117296, DOI: 10.1002/npr2.12027.Peer-Reviewed Original ResearchQuantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system.
Nakamura T, Nakajima K, Ohnishi T, Yoshikawa T, Nakanishi M, Takumi T, Tsuboi T, Kato T. Quantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system. Sci Rep 2018, 8: 16025. PMID: 30375401, DOI: 10.1038/s41598-018-34270-5.Peer-Reviewed Original ResearchIntegrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder.
Takata A, Miyake N, Tsurusaki Y, Fukai R, Miyatake S, Koshimizu E, Kushima I, Okada T, Morikawa M, Uno Y, Ishizuka K, Nakamura K, Tsujii M, Yoshikawa T, Toyota T, Okamoto N, Hiraki Y, Hashimoto R, Yasuda Y, Saitoh S, Ohashi K, Sakai Y, Ohga S, Hara T, Kato M, Nakamura K, Ito A, Seiwa C, Shirahata E, Osaka H, Matsumoto A, Takeshita S, Tohyama J, Saikusa T, Matsuishi T, Nakamura T, Tsuboi T, Kato T, Suzuki T, Saitsu H, Nakashima M, Mizuguchi T, Tanaka F, Mori N, Ozaki N, Matsumoto N. Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder. Cell Rep 2018, 22: 734-747. PMID: 29346770, DOI: 10.1016/j.celrep.2017.12.074.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor Toshihiko Tokizane Memorial Award for Excellent Study in Neuroscience
Regional AwardJapan Neuroscience societyDetails07/01/2022Japanhonor Ichikou Memorial Award
Regional AwardThe University of TokyoDetails03/23/2020Japan