Walter S. Mathis, MD
Associate Professor of PsychiatryCards
About
Research
Publications
2025
HONE: A learning health system platform for advancing early intervention in first episode psychosis
Mathis W, Gibbs-Dean T, Cahill J, Srihari V. HONE: A learning health system platform for advancing early intervention in first episode psychosis. Schizophrenia Research 2025, 280: 1-9. PMID: 40209525, PMCID: PMC12052476, DOI: 10.1016/j.schres.2025.04.009.Peer-Reviewed Original ResearchConceptsLearning health systemEarly intervention servicesFirst-episode psychosisLearning health system frameworkQuality improvementDiverse healthcare settingsContinuous quality improvementMental health outcomesUser-centered designPatient-reported outcomesEvidence-based outcomesDiverse data sourcesCare deliveryEpisode psychosisImprove careKnowledge translationHealth outcomesHealth systemHealthcare settingsLifetime illnessHealthcare reformData visualizationUser engagementTransformation frameworkDuration of untreated psychosisError in Author Affiliation.
. Error in Author Affiliation. JAMA Netw Open 2025, 8: e2511341. PMID: 40232730, DOI: 10.1001/jamanetworkopen.2025.11341.Peer-Reviewed Original ResearchThe STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis
Yoviene Sykes L, Levine N, Tayfur S, Gibbs-Dean T, Hazan H, Imetovski S, James J, Karmani S, Mathis W, Markovich P, Purushothaman D, Riley S, Tek C, Veillette C, Cahill J, Giard J, Marracino A, Barrette K, Bozak S, Gregory F, McDermott G, Srihari V. The STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis. Schizophrenia Research 2025, 278: 96-108. PMID: 40132282, PMCID: PMC11981821, DOI: 10.1016/j.schres.2025.03.029.Peer-Reviewed Original ResearchConceptsLearning healthcare systemLearning CollaborativeHealthcare systemSchizophrenia spectrum disordersPopulation health outcomesLearning health systemSystems of careCare modelHigh-quality treatmentStage of illnessHealth outcomesHealth systemWorkforce developmentDuration of untreated psychosisStatewide systemEarly stages of illnessEarly psychosisWorkforce readinessStrengthening integrationPolicy advocacyLeverage informaticsCareEpisode psychosisStakeholder engagementUntreated psychosisVulnerability Index Approach to Identify Pharmacy Deserts and Keystone Pharmacies
Mathis W, Berenbrok L, Kahn P, Appolon G, Tang S, Hernandez I. Vulnerability Index Approach to Identify Pharmacy Deserts and Keystone Pharmacies. JAMA Network Open 2025, 8: e250715. PMID: 40080019, PMCID: PMC11907307, DOI: 10.1001/jamanetworkopen.2025.0715.Peer-Reviewed Original ResearchConceptsNational Council for Prescription Drug ProgramsPharmacy desertsSmall rural areasCross-sectional studyPharmacy accessCensus tractsPopulation-based cross-sectional studyRural areasLow-income areasHealth equityPrescription drug programPharmacy servicesMedication dispensingCommunity pharmaciesMain OutcomesTargeted policy interventionsPharmacy dataPrimary exposureSignificant disparitiesNearest pharmacyReimbursement ratesAt-riskPharmacyPublic healthPoint-of-care testingGeographic Disparities in Access to Gastroenterologists in the United States
Ying X, Yao L, Mathis W, Congly S, Jesudian A. Geographic Disparities in Access to Gastroenterologists in the United States. Gastroenterology 2025, 168: 1189-1191.e1. PMID: 39922544, DOI: 10.1053/j.gastro.2025.01.232.Peer-Reviewed Original Research
2024
The anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis
Nicholls-Mindlin J, Hazan H, Zhou B, Li F, Ferrara M, Levine N, Riley S, Karmani S, Mathis W, Keshavan M, Srihari V. The anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis. BJPsych Open 2024, 10: e216. PMID: 39628123, PMCID: PMC11698182, DOI: 10.1192/bjo.2024.813.Peer-Reviewed Original ResearchReflections on inductive thematic saturation as a potential metric for measuring the validity of an inductive thematic analysis with LLMs
De Paoli S, Mathis W. Reflections on inductive thematic saturation as a potential metric for measuring the validity of an inductive thematic analysis with LLMs. Quality & Quantity 2024, 59: 683-709. DOI: 10.1007/s11135-024-01950-6.Peer-Reviewed Original ResearchInductive thematic analysis of healthcare qualitative interviews using open-source large language models: How does it compare to traditional methods?
Mathis W, Zhao S, Pratt N, Weleff J, De Paoli S. Inductive thematic analysis of healthcare qualitative interviews using open-source large language models: How does it compare to traditional methods? Computer Methods And Programs In Biomedicine 2024, 255: 108356. PMID: 39067136, DOI: 10.1016/j.cmpb.2024.108356.Peer-Reviewed Original ResearchLanguage modelThematic analysisInductive thematic analysisQualitative thematic analysisGenerative artificial intelligenceSemi-structured interviewsLocal hardwareArtificial intelligenceHealth informationReal worldPsychiatric settingsHuman codingQualitative interviewsQualitative dataEvaluation methodologyQuantify similarityRobust themesThemesResearch settingsTraditional methodsEngineering techniquesInterviewsEvaluation methodQualitative researchCorpus of interviewsTimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis
Mathis W, Ferrara M, Cahill J, Karmani S, Tayfur S, Srihari V. TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis. PLOS ONE 2024, 19: e0302116. PMID: 39028697, PMCID: PMC11259254, DOI: 10.1371/journal.pone.0302116.Peer-Reviewed Original ResearchConceptsPathways to CareDuration of untreated psychosisManual transcription errorsDevelopment of targeted interventionsReduce duration of untreated psychosisHealthcare accessibility researchReal-time data entryImprove patient outcomesEpisode psychosisCare pathwaysPatient journeyHealthcare contextPatient outcomesPaper-basedConversion of collected dataFEP treatmentData collection processNew HavenData collection methodsData entryTranscription errorsUntreated psychosisOpen-source codebaseData collectionWeb-based toolEmpirically-derived, locally responsive travel time thresholds for optimal geographic supermarket access using national commuting data
Mathis W, Kahn P, Tang S, Berenbrok L, Hernandez I. Empirically-derived, locally responsive travel time thresholds for optimal geographic supermarket access using national commuting data. Journal Of Transport Geography 2024, 118: 103945. DOI: 10.1016/j.jtrangeo.2024.103945.Peer-Reviewed Original ResearchTravel time thresholdFood access researchRural blockSpatial accessibilityNew York CitySparsely populated regionsCommuting dataCensus tractsGeographic accessFood accessSupermarket accessCommunity resourcesUrban centersLos AngelesYork CityAccessibility researchUrban blocksUnited StatesRegional differencesRegion of northern CaliforniaUS DepartmentAccessCensusMethodological advancesGreat Plains
News
News
- June 04, 2025
Dr. Michael J. Sernyak, Jr. You Made a Difference Awards Presented at CMHC
- April 11, 2025
A New Metric to Identify—and Prevent—Pharmacy Deserts
- March 14, 2025Source: JAMA Network Open
Vulnerability Index Approach to Identify Pharmacy Deserts and Keystone Pharmacies
- July 26, 2024Source: Computer Methods and Programs in Biomedicine
Inductive Thematic Analysis of Healthcare Qualitative Interviews Using Open-Source Large Language Models: How Does it Compare to Traditional Methods?