Woo Sub Yang
Associate Research Scientist in GeneticsAbout
Research
Publications
2024
Homoplantaginin Antagonizes N‑Methyl‑d‑aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity
Chen T, Chen Y, Hsu M, Liao Y, Wu C, Yao C, Yang W, Lin W, Lin Y. Homoplantaginin Antagonizes N‑Methyl‑d‑aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity. Journal Of Agricultural And Food Chemistry 2024, 72: 28294-28304. PMID: 39661093, DOI: 10.1021/acs.jafc.4c07659.Peer-Reviewed Original ResearchConceptsCalcium influxAntagonize N-methyl-D-aspartate receptorsExtracellular signal-regulated kinase signalingAlzheimer's diseaseN-methyl-D-aspartate receptorsImpairment of novel object recognitionNMDA-induced calcium influxMembrane potential sensitive dyeIntracellular calcium measurementsNovel object recognitionKinase signalingAMPA insultClinical therapeutic drugsPotential sensitive dyeERK phosphorylationGlutamatergic neuronsReceptor levelsCalcium measurementsMouse modelSpatial learning/memoryBehavioral testsTherapeutic drugsAnimal behaviorAbnormal depolarizationNatural compoundsCrosstalk Within the Intestinal Epithelium: Aspects of Intestinal Absorption, Homeostasis, and Immunity
Yu L, Yang W, Liang Y. Crosstalk Within the Intestinal Epithelium: Aspects of Intestinal Absorption, Homeostasis, and Immunity. Biomedicines 2024, 12: 2771. DOI: 10.3390/biomedicines12122771.Peer-Reviewed Original ResearchIntestinal epithelial cellsEnteroendocrine cellsIntestinal epithelial stem cellsGut healthPaneth cellsTufted cellsIntestinal functionHealthy gastrointestinal tractNutrient transporter activityActivate Notch signalingEpithelial stem cellsIntestinal cell modelGastrointestinal tractIntestinal absorptionInfluence intestinal functionIntestinal homeostasisRegulation pathwaysGoblet cellsNotch signalingRegulation of intestinal functionCell typesImmune cellsIntestinal epitheliumAgricultural animalsIntestinal immunityTranscriptomics and gut microbiome analysis of the edible herb Bidens pilosa as a functional feed additive to promote growth and metabolism in tilapia (Oreochromis spp.)
Chen C, Lin C, Lu H, Liou C, Ho Y, Huang C, Zhang Z, Kao C, Yang W, Gong H. Transcriptomics and gut microbiome analysis of the edible herb Bidens pilosa as a functional feed additive to promote growth and metabolism in tilapia (Oreochromis spp.). BMC Genomics 2024, 25: 785. PMID: 39138417, PMCID: PMC11323441, DOI: 10.1186/s12864-024-10674-8.Peer-Reviewed Original ResearchConceptsGrowth performanceGut microbiotaB. pilosaAmino acid metabolismGrowth performance of tilapiaSignal transductionGut microbiota of fishMultifunctional feed additiveEnhanced growth performanceExpression of myogenic regulatory factorsPromote muscle growthMicrobiota of fishAmino acidsAcid metabolismComparative transcriptome analysisCarbohydrate metabolismMyogenic regulatory factorsWeeks of feedingComposition of gut bacteriaGut microbiome analysisMuscle growthKEGG enrichment resultsLipid metabolismGrowth-associated genesFunctional enrichment analysisTranscriptomic Insights and the Development of Microsatellite Markers to Assess Genetic Diversity in the Broodstock Management of Litopenaeus stylirostris
Yang Y, Chu P, Chen C, Yang W, Hsu T, Gong H, Liao I, Huang C. Transcriptomic Insights and the Development of Microsatellite Markers to Assess Genetic Diversity in the Broodstock Management of Litopenaeus stylirostris. Animals 2024, 14: 1685. PMID: 38891732, PMCID: PMC11171113, DOI: 10.3390/ani14111685.Peer-Reviewed Original ResearchGenetic diversityMicrosatellite markersTranscriptome databaseDevelopment of microsatellite markersIllumina HiSeq 4000 platformMitigate inbreeding depressionAssessed genetic diversityDisease resistance pathwaysReduced genetic diversityHiSeq 4000 platformModerate genetic variabilityFunctional gene analysisReduce disease susceptibilityDevelopment of markersSignificant inbreedingBlack tiger shrimpFarmed shrimp populationsFunctional annotationInbreeding depressionDinucleotide repeatsTranscriptomic insightsMicrosatellite analysisTranscriptome-basedDiversity analysisGenetic variabilityFunctional and mechanistic studies of a phytogenic formulation, Shrimp Best, in growth performance and vibriosis in whiteleg shrimp
Lee Y, Umam K, Kuo T, Yang Y, Feng C, Yang W. Functional and mechanistic studies of a phytogenic formulation, Shrimp Best, in growth performance and vibriosis in whiteleg shrimp. Scientific Reports 2024, 14: 11584. PMID: 38773245, PMCID: PMC11109214, DOI: 10.1038/s41598-024-62436-x.Peer-Reviewed Original ResearchConceptsGrowth performanceWhiteleg shrimpV. parahaemolyticusDecreased feed conversion ratioFeed conversion ratioShrimp body weightInhibited V. parahaemolyticusRegulation of gut microbiotaRRNA sequence dataBacterial membrane destructionShrimp gutConversion ratioShrimp farmingSequence dataL. johnsoniiVibrio parahaemolyticusGut microbiotaVibriosisShrimpPathogenic bacteriaVibrioIn vitro regulationFunctional studiesFatty acidsBody weightNovel Experimental Mouse Model to Study the Pathogenesis and Therapy of Actinobacillus pleuropneumoniae Infection
Bui D, Lee Y, Kuo T, Chen Z, Yang W. Novel Experimental Mouse Model to Study the Pathogenesis and Therapy of Actinobacillus pleuropneumoniae Infection. Pathogens 2024, 13: 412. PMID: 38787263, PMCID: PMC11123673, DOI: 10.3390/pathogens13050412.Peer-Reviewed Original ResearchActinobacillus pleuropneumoniaeActinobacillus pleuropneumoniae infectionActinobacillus pleuropneumoniae strainsPleuropneumoniae infectionDays of infectionGenetic resourcesSerovars 1Lung infectionInfected BALB/c miceMouse modelRespiratory tract of miceSurvival rate of miceAirway bacterial infectionExperimental mouse modelRate of miceBody weight lossPigsClinical symptomsBALB/c miceLung damageMouse lungHistological examinationSurvival rateBacterial infectionsExperimental miceA wearable hydraulic shock absorber with efficient energy dissipation
Cecchi N, Liu Y, Vegesna R, Zhan X, Yang W, Campomanes L, Grant G, Camarillo D. A wearable hydraulic shock absorber with efficient energy dissipation. International Journal Of Mechanical Sciences 2024, 270: 109097. DOI: 10.1016/j.ijmecsci.2024.109097.Peer-Reviewed Original ResearchHydraulic shock absorberHydraulic shockEnergy absorption ratioEnergy dissipationShock absorberStable energy dissipationImpact loading conditionsMechanism of energy absorptionAbsorbing technologyEfficient energy dissipationImpact loadingLoading conditionsDesign parametersEnergy absorptionAbsorption ratioFluid flowSoft structuresTolerance sizeDissipationState-of-the-artAbsorberDevicesSoftnessEnergyLoadComputational approaches for mechanobiology in cardiovascular development and diseases
Brown A, Sexton Z, Hu Z, Yang W, Marsden A. Computational approaches for mechanobiology in cardiovascular development and diseases. Current Topics In Developmental Biology 2024, 156: 19-50. PMID: 38556423, DOI: 10.1016/bs.ctdb.2024.01.006.Peer-Reviewed Original ResearchCardiovascular developmentCongenital heart diseaseMechanical cuesCell biologyDevelopmental mechanismsClinical studiesDisease etiologyTreatment outcomesCardiac developmentEnhance treatment outcomesHeart diseaseClinical practiceComputational hemodynamics modelsMechanobiologyContext of treatmentComputational approachRemodeling processDiseaseTissue growthComputational toolsAnatomical structuresBlood flow dynamics
2012
Catenarin, an anthraquinone compound, inhibits CXCR4 and CCR5 pathways to protect against type 1 diabetes in NOD mice (72.1)
Yang W, Shen M, Jang Y, Chen Z, Chang C. Catenarin, an anthraquinone compound, inhibits CXCR4 and CCR5 pathways to protect against type 1 diabetes in NOD mice (72.1). The Journal Of Immunology 2012, 188: 72.1-72.1. DOI: 10.4049/jimmunol.188.supp.72.1.Peer-Reviewed Original ResearchType 1 diabetesC-C chemokine receptor type 5Chemokine receptor type 5Expression of CCR5Non-obese diabetic miceCXCR4-mediated chemotaxisCCR5 pathwayNOD micePhosphorylation of mitogen-activated protein kinasesCalcium mobilizationDose-dependentlyMitogen-activated protein kinaseProphylactic agentInflammatory diseasesInhibit CXCR4Cell lossDiabetic miceCCR5Anti-inflammatory compoundsType 5Leukocyte migrationPreventive effectT1DAbstract InflammationCXCR4
2011
Role of myeloid-derived suppressor cells in type 1 diabetes (167.16)
Yen C, Chen S, Pan P, Pan C, Yang W. Role of myeloid-derived suppressor cells in type 1 diabetes (167.16). The Journal Of Immunology 2011, 186: 167.16-167.16. DOI: 10.4049/jimmunol.186.supp.167.16.Peer-Reviewed Original ResearchMyeloid-derived suppressor cellsType 1 diabetesSuppressor cellsNOD/SCID miceT cellsMechanisms of action of MDSCsPresence of myeloid-derived suppressor cellsAutoimmune diseasesAutoimmune destruction of pancreatic isletsInduction of peripheral toleranceSuppression of T cell proliferationCD4+CD25+Foxp3+ TregsT cell suppressionDiabetic NOD miceInflammatory T cellsSingle-dose treatmentT cell proliferationAbstract Type 1 diabetesSuppress immune responsesDestruction of pancreatic isletsAnti-inflammation cytokinesSuppressed T1DAdoptive transferEffective immunotherapyPeripheral tolerance
Get In Touch
Contacts
Email