Xing Feng
Associate Research ScientistAbout
Research
Publications
2023
Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression
Zhang H, Chen G, Feng X, Song H, Meng L, Fu Y, Yang J, Fan Z, Ding Y, Du Z, Wang J, Yang L, Zhang J, Sun L, Liu Z, Zhang Z, Li Q, Fan X. Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression. EMBO Molecular Medicine 2023, 15: emmm202215924. PMID: 36947051, PMCID: PMC10165360, DOI: 10.15252/emmm.202215924.Peer-Reviewed Original ResearchConceptsMyeloid-derived suppressor cellsImmune microenvironmentReduces CD8<sup>+</sup> T cell infiltrationIntratumoral myeloid-derived suppressor cellsCD8<sup>+</sup> T cell infiltrationAnti-PD-L1Orthotopically implanted tumorsT cell infiltrationHepa1-6 cellsCapacity of HCC cellsInvasive capacity of HCC cellsSuppressor cellsLung metastasesPoor prognosisC57BL/6J miceHepatocellular carcinoma progressionImmunosuppressive effectsCarcinoma progressionTNFA locusNF-kBHCCHCC cellsFunctional lossTNFAHCC progression
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