Yuan Lu, ScD
Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)Cards
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Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)
Biography
Dr. Lu was trained in epidemiology and global health, with a particular focus on cardiovascular diseases. She obtained both of her ScD and MSc Degrees in Global Health and Population at the Harvard School of Public Health. She works in the intersection of cardiovascular disease prevention, clinical informatics, and digital health, using implementation science methods to resolve real-world issues. Her long-term goal is to improve care and outcomes of cardiovascular diseases by designing and implementing technology-based interventions.
She successfully completed an NHLBI K12 career development award in implementation science. During this award, she harnessed electronic health records from the Yale New Haven Health System to identify patients with persistent hypertension and designing decision support systems to improve their care. Currently, Dr. Lu serves as the Principal Investigator for an NIH R01 grant, where she leverages real-world data from five electronic health record databases encompassing over 100 million US adults. The goal of this endeavor is to generate real-world evidence that informs decisions regarding hypertension treatment escalation.
In addition to her domestic contributions, Dr. Lu has engaged in groundbreaking collaborative projects between Yale University and the Chinese National Center for Cardiovascular Diseases in Beijing. These include the Millions Persons Project that assembles remarkable population health and biomedical resources from 5 million individuals across China. Moreover, she has collaborated with the NCD Risk Factor Collaboration (NCD-RisC) on global analyses examining the impact of risk factors on the worldwide burden of cardiovascular diseases.
She has authored over 150 peer-reviewed publications, including first author articles in leading journals such as The Lancet, JAMA, BMJ, Circulation, and JACC, and her work has been cited more than 50,000 times. Dr. Lu is the recipient of the 2022 John H. Laragh Research Award of the American Journal of Hypertension for her contribution to the field of hypertension. She is a Fellow of the American Heart Association and the American College of Cardiology, and currently serves as an Executive Associate Editor at JACC.
Appointments
Cardiovascular Medicine 4
Assistant ProfessorPrimaryBiomedical Informatics & Data Science
Assistant ProfessorSecondaryChronic Disease Epidemiology
Assistant ProfessorSecondary
Other Departments & Organizations
- All Institutions
- Biomedical Informatics & Data Science
- Cardiovascular Medicine 4
- Center for Outcomes Research & Evaluation (CORE)
- Chronic Disease Epidemiology
- Internal Medicine
- Janeway Society
- Preventive Cardiovascular Health Program at Yale
- Yale UNRAVEL Study
Education & Training
- ScD
- Harvard School of Public Health, Global Health and Population (2015)
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-5264-2169- View Lab Website
Yale/YNHH Center for Outcomes Research and Evaluation (CORE)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Harlan Krumholz, MD, SM
Erica Spatz, MD, MHS
Rohan Khera, MD, MS
Mitsuaki Sawano, MD, PhD
Shiwani Mahajan, MBBS, MHS
Jeph Herrin, PhD
Cardiovascular Diseases
Chronic Disease
Publications
2025
Evaluating Blood Pressure Response Patterns to Exercise Stress Testing.
Nene A, Lee D, Agboola O, Herrin J, Onuma OK, Feher A, Miller EJ, Lu Y, Meadows J, Spatz ES. Evaluating Blood Pressure Response Patterns to Exercise Stress Testing. Hypertension 2025 PMID: 40859827, DOI: 10.1161/HYPERTENSIONAHA.124.23717.Peer-Reviewed Original ResearchChanges in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide
Lu Y, Liu Y, Totojani T, Kim C, Khera R, Xu H, Brush J, Krumholz H, Abaluck J. Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide. JAMA Network Open 2025, 8: e2526013. PMID: 40779264, PMCID: PMC12334959, DOI: 10.1001/jamanetworkopen.2025.26013.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsHealth care expendituresCardiovascular risk factorsCare expendituresCohort studyRisk factorsYale New Haven Health SystemCohort study of adultsType 2 diabetes statusLong-term impactStudy of adultsHealth systemRetrospective cohort studyBlood pressureHemoglobin A1c reductionMain OutcomesTotal cholesterolSentara HealthcareInpatient staySecondary outcomesGlucagon-like peptide-1 receptor agonistsPrimary outcomeHealthPeptide-1 receptor agonistsAssociated with clinical outcomesAssociated with reductionsJACC Data Report Cardiovascular Disease Mortality Trends in the United States (1999-2023)
Yan B, Arun A, Curtis L, Kadakia K, Lin Z, Lu Y, Wadhera R, Krumholz H, Dhruva S. JACC Data Report Cardiovascular Disease Mortality Trends in the United States (1999-2023). Journal Of The American College Of Cardiology 2025, 85: 2495-2498. PMID: 40562514, DOI: 10.1016/j.jacc.2025.05.018.Peer-Reviewed Original ResearchCitationsAltmetricUptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
Kim C, Ross J, Jastreboff A, Meeker D, Freedman H, Krumholz H, Lu Y. Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US. JAMA 2025, 333: 2203-2206. PMID: 40299371, PMCID: PMC12042086, DOI: 10.1001/jama.2025.4735.Peer-Reviewed Original ResearchCitationsAltmetricLeveraging Global Data to Illuminate Pediatric Heart Failure Promise, Gaps, and the Path Forward
Lu Y. Leveraging Global Data to Illuminate Pediatric Heart Failure Promise, Gaps, and the Path Forward. JACC Heart Failure 2025, 13: 102500. PMID: 40540985, DOI: 10.1016/j.jchf.2025.04.011.Peer-Reviewed Original ResearchLipid-Lowering Therapy in the U.S. Adults Before and After the COVID-19 Pandemic
Essa M, Malik D, Lu Y, Yang H, Spatz E, Krumholz H, Faridi K. Lipid-Lowering Therapy in the U.S. Adults Before and After the COVID-19 Pandemic. JACC Advances 2025, 4: 101872. PMID: 40513221, PMCID: PMC12205634, DOI: 10.1016/j.jacadv.2025.101872.Peer-Reviewed Original ResearchRisk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study.
Morales D, Bu F, Viernes B, DuVall S, Matheny M, Simon K, Falconer T, Richter L, Ostropolets A, Lau W, Man K, Chattopadhyay S, Mathioudakis N, Minty E, Nishimura A, Sun F, Yin C, Seager S, Chai Y, Zhou J, Lu Y, Reyes C, Pistillo A, Duarte-Salles T, Blacketer C, Schuemie M, Ryan P, Krumholz H, Hripcsak G, Khera R, Suchard M. Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study. Diabetes Care 2025 PMID: 40465422, DOI: 10.2337/dc25-0154.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRisk of thyroid tumorThyroid tumorsGLP-1RADPP-4isHazard ratioThyroid malignancyCohort studyIncreased riskSodium-glucose cotransporter 2 inhibitorsElectronic health record databaseGlucagon-like peptide 1 receptor agonistsEstimate hazard ratiosRandom-effects meta-analysisGLP-1 receptor agonistsPeptide 1 receptor agonistsDipeptidyl peptidase 4 inhibitorsThyroid tumor incidenceUsers of SGLT2isHealth record databaseSecond-line treatmentType 2 diabetes mellitusNew-user cohort studyRetrospective cohort studyUsers of sulfonylureasIntention-to-treatJoint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States.
Chu L, Wang R, Gross C, Wei J, Lu Y, Krumholz H, Ma X, Chen K. Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States. Circulation 2025 PMID: 40458867, DOI: 10.1161/circulationaha.124.073614.Peer-Reviewed Original ResearchAltmetricConceptsIncident acute myocardial infarctionAcute myocardial infarctionIncreased oddsRisk of acute myocardial infarctionHigher risk of acute myocardial infarctionProbability of acute myocardial infarctionOccurrence of acute myocardial infarctionRandom-effects meta-analysisCase-crossover studyMultivariate random-effects meta-analysisExposure to ozoneRegion-specific estimatesMyocardial infarctionStatistical interaction termsAmbient ozone pollutionPrevention strategiesUnited StatesJoint exposureMeta-analysisAdult ageYoung adultsHigh riskAdultsOddsInteraction termsTrends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores
Yang H, Huang C, Sawano M, Herrin J, Faridi K, Li Z, Spatz E, Krumholz H, Lu Y. Trends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores. JAMA Network Open 2025, 8: e2516663. PMID: 40531529, PMCID: PMC12177675, DOI: 10.1001/jamanetworkopen.2025.16663.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsLife's Essential 8 scoreLife's Essential 8Cross-sectional studyWhite differencesEthnic differencesNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveySleep health scoreNutrition Examination SurveyGroup-specific interventionsPrimary positive factorPhysical activityExamination SurveyHealth scoresBlack adultsWhite adultsMain OutcomesAsian adultsOverall scoreEvaluate trendsNicotine exposureEssential 8Blood lipidsAdultsEthnic groupsThe 2025 Guideline for the Management of Patients With Acute Coronary Syndromes Asian Perspective
Sawano M, Du X, Wong N, You S, Park D, Kubo T, Kondo T, Seth A, Nasir K, Ko D, Lu Y, Wang J. The 2025 Guideline for the Management of Patients With Acute Coronary Syndromes Asian Perspective. Journal Of The American College Of Cardiology 2025, 85: 2114-2117. PMID: 40467142, DOI: 10.1016/j.jacc.2025.04.011.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Activities
activity National Institutes of Health (NIH)
06/01/2023 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity JACC
02/01/2024 - PresentJournal ServiceAssociate Editoractivity American Heart Association
07/01/2021 - PresentProfessional OrganizationsFellowactivity JACC
07/01/2024 - PresentJournal ServiceAssociate Editoractivity American College of Cardiology
03/01/2025 - PresentProfessional OrganizationsFellow
Honors
honor Fellow
03/01/2025National AwardAmerican College of CardiologyDetailsUnited Stateshonor Office of Health Equity Research Award for Yale Research Excellence, Finalist
02/23/2024Yale School of Medicine AwardOffice of Health Equity Research, Yale School of MedicineDetailsUnited Stateshonor Office of Health Equity Research Award for Yale Research Excellence
02/01/2023Yale University AwardOffice of Health Equity Research, Yale School of MedicineDetailsUnited Stateshonor The John Laragh Research Award
07/29/2022National AwardAmerican Journal of HypertensionDetailsUnited Stateshonor Batten Fellowship Award
07/01/2022Regional AwardSentara FoundationDetailsUnited States
Teaching & Mentoring
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Mentoring
Chungsoo Kim
Postdoc2024 - PresentIvan Wu
Postgrad associate2024 - PresentAdith Arun
Medical student2024 - PresentXin Xin
Graduate student2023 - 2024
News
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News
- July 14, 2025Source: Cardiologytoday
Delays in Hypertension Diagnosis May Hold Up Treatment, Increase CVD Risk
- June 03, 2025Source: Yale News
Insights & Outcomes: Star Music, Kavli Kudos, and Summertime Heart Risks
- May 05, 2025
Why Aren’t People Who Need Weight Loss Drugs Getting Them?
- April 17, 2025
Lower Blood Pressure May Offer Benefits Even for the Very Elderly
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Yale Center for Outcomes Research and Evaluation
Academic Office
195 Church Street, Fl 5th
New Haven, CT 06510