Therapeutic targeting of ATR in alveolar rhabdomyosarcoma
Dorado García H, Pusch F, Bei Y, von Stebut J, Ibáñez G, Guillan K, Imami K, Gürgen D, Rolff J, Helmsauer K, Meyer-Liesener S, Timme N, Bardinet V, Chamorro González R, MacArthur I, Chen C, Schulz J, Wengner A, Furth C, Lala B, Eggert A, Seifert G, Hundsoerfer P, Kirchner M, Mertins P, Selbach M, Lissat A, Dubois F, Horst D, Schulte J, Spuler S, You D, Dela Cruz F, Kung A, Haase K, DiVirgilio M, Scheer M, Ortiz M, Henssen A. Therapeutic targeting of ATR in alveolar rhabdomyosarcoma. Nature Communications 2022, 13: 4297. PMID: 35879366, PMCID: PMC9314382, DOI: 10.1038/s41467-022-32023-7.Peer-Reviewed Original ResearchConceptsCRISPR activation screenAlveolar rhabdomyosarcomaATR inhibitionGenome-wide CRISPR activation screenClinical outcomes of patientsMulti-modal treatment approachSensitivity to ATR inhibitionOutcomes of patientsPAX3-FOXO1Rad3 related proteinMuscle progenitor cellsDNA repair pathway activityClinical outcomesInhibition in vitroATR inhibitorsProgenitor cellsClinical trialsBRCA1 phosphorylationRas-MAPK pathwayCombined treatmentARMS cellsPARP1 inhibitorsAtaxia telangiectasiaRhabdomyosarcoma cellsTreatment approaches
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