Yu Sun
Associate Research Scientist in NeuroscienceCards
About
Research
Publications
2025
Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39
Fu Z, Ganesana M, Hwang P, Tan X, Kinkaid M, Sun Y, Bian E, Weybright A, Chen H, Sol-Church K, Eyo U, Pridans C, Quintana F, Robson S, Kumar P, Venton B, Schaefer A, Kuan C. Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39. Nature Communications 2025, 16: 956. PMID: 39843911, PMCID: PMC11754601, DOI: 10.1038/s41467-025-56093-5.Peer-Reviewed Original ResearchConceptsCerebral blood flowEctonucleotidases CD39Whisker stimulationResponse to whisker stimulationCerebrovascular reactivityDeletion of CD39Blood flowInjection of adenosine triphosphateModulation of cerebral blood flowRegulation of cerebral blood flowExtracellular adenosine triphosphateInjection of adenosineBorder-associated macrophagesMicroglia repopulationExtracellular adenosineAdenosine triphosphateFemale miceBlood flow anomaliesP2RY12 receptorCo-transmitterMouse modelPharmacological inhibitionCD39MicrogliaMice
2024
Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis
Tang H, Du S, Niu Z, Zhang D, Tang Z, Chen H, Chen Z, Zhang M, Xu Y, Sun Y, Fu X, Norback D, Shao J, Zhao Z. Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis. BMC Microbiology 2024, 24: 505. PMID: 39614169, PMCID: PMC11606197, DOI: 10.1186/s12866-024-03668-9.Peer-Reviewed Original ResearchConceptsSpecies levelBacterial speciesAR childrenNasal cavityMethodsIn this case–control studyBody sitesControl groupBacterial diversityCase-control studyB-diversityOral swab samplesS. epidermidisStaphylococcus epidermidisStaphylococcus aureusBacterial characterizationMicrobesAllergic rhinitisSpeciesHealthy subjectsBackgroundAllergic rhinitisSwab samplesHealthy onesConclusionsOur studyMicroorganismsRhinitisExploring the role of genetics, gut microbiota and blood metabolites in IBD
Yuan Y, Fu X, Deng Y, Sun Y. Exploring the role of genetics, gut microbiota and blood metabolites in IBD. Gut 2024, gutjnl-2024-333611. PMID: 39366724, DOI: 10.1136/gutjnl-2024-333611.Peer-Reviewed Original ResearchZearalenone-induced hepatointestinal toxicity in laying hens: unveiling the role of gut microbiota and fecal metabolites
Wang L, Deng Z, Huang J, Li T, Jiang J, Wang W, Sun Y, Deng Y. Zearalenone-induced hepatointestinal toxicity in laying hens: unveiling the role of gut microbiota and fecal metabolites. Poultry Science 2024, 103: 104221. PMID: 39241615, PMCID: PMC11406091, DOI: 10.1016/j.psj.2024.104221.Peer-Reviewed Original ResearchGut microbiotaGut microbial community compositionGut microbial diversityLaying hensMicrobial community compositionMetabolism of amino acidsNonribosomal peptidesCommunity compositionRRNA sequencingExacerbated liver damageFusarium speciesMicrobial diversityFirmicutes/Bacteroidetes ratioNucleic acid degradationInflammatory cell infiltrationABC transportersAspartate aminotransferaseEstrogenic disordersLactobacillus abundanceDecreased villus heightHigher abundanceMicrobiotaIntestinal oxidative stressZearalenone groupsAmino acidsCaspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity
Sun Y, Lu Y, Liu L, Saaoud F, Shao Y, Xu K, Drummer C, Cueto R, Shan H, Jiang X, Zhao H, Wang H, Yang X. Caspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity. JCI Insight 2024, 9: e177229. PMID: 39024553, PMCID: PMC11343595, DOI: 10.1172/jci.insight.177229.Peer-Reviewed Original ResearchChronic kidney diseaseTrained immunityAortic endothelial cellsVascular inflammationEndothelial cellsRecruitment of macrophagesIL-1b levelsHuman aortic endothelial cellsHigh-fat dietMembrane expressionN-terminal gasdermin DCytokine secretionPathological analysisIL-1BKidney diseaseNeointima hyperplasiaCaspase-4/11HyperlipidemiaInflammationCytosolic lipopolysaccharideCaspase-11RNA sequencingGasdermin DImmunityLipopolysaccharidePyrroloquinoline quinone production defines the ability of Devosia species to degrade deoxynivalenol
Guo C, Wen J, Sun Y, Liang G, Wang Z, Pan L, Huang J, Liao Y, Wang Z, Chen Q, Mu P, Deng Y. Pyrroloquinoline quinone production defines the ability of Devosia species to degrade deoxynivalenol. Food & Function 2024, 15: 6134-6146. PMID: 38767386, DOI: 10.1039/d4fo00024b.Peer-Reviewed Original ResearchPyrroloquinoline quinone productionPyrroloquinoline quinoneProduction of deoxynivalenolHEK293T cellsGenome comparisonDevosia speciesGene clusterDegradation activitySynthesis genesCompound C.Contaminates cereal cropsAnimal feed industryDON detoxificationDegrading bacteriumSynthesis abilityCell viability assayDegrading strainsDegrading bacteriaCereal cropsAnimal feedFeed industryCulture mediumGenesDeoxynivalenol degradationStrainCDGSH iron-sulfur domain 2 as a therapeutic target for stroke: an opinion article
Feng C, Chen W, Kung W, Sun Y, Lin M. CDGSH iron-sulfur domain 2 as a therapeutic target for stroke: an opinion article. Frontiers In Molecular Neuroscience 2024, 17: 1386118. PMID: 38864028, PMCID: PMC11165110, DOI: 10.3389/fnmol.2024.1386118.Peer-Reviewed Original ResearchEditorial: Environmental microbiomes, metabolites, and respiratory diseases
Fu X, Norbäck D, Sun Y. Editorial: Environmental microbiomes, metabolites, and respiratory diseases. Frontiers In Microbiomes 2024, 3: 1388525. DOI: 10.3389/frmbi.2024.1388525.Peer-Reviewed Original ResearchReducing brain Aβ burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice
Tsay H, Gan Y, Su Y, Sun Y, Yao H, Chen H, Hsu Y, Hsu J, Wang H, Shie F. Reducing brain Aβ burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice. Biomedicine & Pharmacotherapy 2024, 173: 116404. PMID: 38471275, DOI: 10.1016/j.biopha.2024.116404.Peer-Reviewed Original ResearchAPP/PS1 miceAmeliorate fatty liver diseaseAlzheimer's diseaseAD-like pathologyHFD-induced hyperglycemiaAD-related pathologyExpression of genesFatty liver diseaseFatty acid oxidationHFD-induced fatty liverAD therapyLipid accumulationHigh-fat diet-induced fatty liver diseaseAPP/PS1HFD feedingCharacteristics of microgliaExposure to HFDHepatic lipogenesisLiver diseaseDiet-induced fatty liver diseaseAcid oxidationHepatic lipidsExploring the role of indoor microbiome and environmental characteristics in rhinitis symptoms among university students
Fu X, Shama A, Norbäck D, Chen Q, Xia Y, Zhang X, Sun Y. Exploring the role of indoor microbiome and environmental characteristics in rhinitis symptoms among university students. Frontiers In Microbiomes 2024, 3: 1277177. DOI: 10.3389/frmbi.2024.1277177.Peer-Reviewed Original ResearchAbundance of taxaIndoor microbiomeClass of actinobacteriaAssociated with rhinitisMicrobiome assemblagesRisk of rhinitisTaxa richnessRRNA sequencingBacterial generaAbundant generaTaxaEnvironmental characteristicsMicrobiomeGenusCO2 concentrationActinobacteriaAbundanceIndoor PM2.5 concentrationsFusobacteriiaSelf-administered questionnaireRhinitis symptomsShanxi UniversityPetri dishesPrevalent chronic respiratory diseasePM2.5 concentrations
Get In Touch
Contacts
Email